| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Deba_0329 | Deba_1636 | Deba_0329 | Deba_1636 | COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR016040:IPR006367; KEGG: sfu:Sfum_1588 siroheme synthase; SPTR: A0LIM3 Precorrin-2 dehydrogenase; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain. | COGs: COG2875 Precorrin-4 methylase; InterPro IPR000878:IPR014777:IPR014776; KEGG: ppd:Ppro_1250 uroporphyrin-III C/tetrapyrrole methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: A1ANF1 Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases. | 0.903 |
| Deba_0329 | Deba_2458 | Deba_0329 | Deba_2458 | COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR016040:IPR006367; KEGG: sfu:Sfum_1588 siroheme synthase; SPTR: A0LIM3 Precorrin-2 dehydrogenase; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain. | COGs: COG2243 Precorrin-2 methylase; InterPro IPR006364:IPR014777:IPR000878:IPR012382; KEGG: sfu:Sfum_2135 precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: A0LK65 Precorrin-2 C20-methyltransferase / cobalt-factor II C20-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase. | 0.938 |
| Deba_0329 | Deba_2460 | Deba_0329 | Deba_2460 | COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR016040:IPR006367; KEGG: sfu:Sfum_1588 siroheme synthase; SPTR: A0LIM3 Precorrin-2 dehydrogenase; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain. | precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; COGs: COG2242 Precorrin-6B methylase 2; InterPro IPR012818:IPR014008:IPR000878:IPR006365; KEGG: dvl:Dvul_0558 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-6Y C(5,15)-methyltransferase (decarboxylating); SPTR: A1VAW5 Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit; TIGRFAM: precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; precorrin-6y C5,15-methyltransferase (d [...] | 0.621 |
| Deba_0329 | Deba_2958 | Deba_0329 | Deba_2958 | COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR016040:IPR006367; KEGG: sfu:Sfum_1588 siroheme synthase; SPTR: A0LIM3 Precorrin-2 dehydrogenase; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain. | Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731:IPR013785; KEGG: dol:Dole_1224 delta-aminolevulinic acid dehydratase; PFAM: delta-aminolevulinic acid dehydratase; PRIAM: Porphobilinogen synthase; SPTR: A8ZY23 Delta-aminolevulinic acid dehydratase; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.632 |
| Deba_0329 | hemC | Deba_0329 | Deba_0814 | COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR016040:IPR006367; KEGG: sfu:Sfum_1588 siroheme synthase; SPTR: A0LIM3 Precorrin-2 dehydrogenase; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.904 |
| Deba_1636 | Deba_0329 | Deba_1636 | Deba_0329 | COGs: COG2875 Precorrin-4 methylase; InterPro IPR000878:IPR014777:IPR014776; KEGG: ppd:Ppro_1250 uroporphyrin-III C/tetrapyrrole methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: A1ANF1 Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases. | COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR016040:IPR006367; KEGG: sfu:Sfum_1588 siroheme synthase; SPTR: A0LIM3 Precorrin-2 dehydrogenase; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain. | 0.903 |
| Deba_1636 | Deba_2457 | Deba_1636 | Deba_2457 | COGs: COG2875 Precorrin-4 methylase; InterPro IPR000878:IPR014777:IPR014776; KEGG: ppd:Ppro_1250 uroporphyrin-III C/tetrapyrrole methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: A1ANF1 Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases. | Precorrin-8X methylmutase; COGs: COG2082 Precorrin isomerase; InterPro IPR003722; KEGG: dba:Dbac_0965 precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase CbiC/CobH; PRIAM: Precorrin-8X methylmutase; SPTR: C0GRL7 Precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase. | 0.938 |
| Deba_1636 | Deba_2458 | Deba_1636 | Deba_2458 | COGs: COG2875 Precorrin-4 methylase; InterPro IPR000878:IPR014777:IPR014776; KEGG: ppd:Ppro_1250 uroporphyrin-III C/tetrapyrrole methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: A1ANF1 Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases. | COGs: COG2243 Precorrin-2 methylase; InterPro IPR006364:IPR014777:IPR000878:IPR012382; KEGG: sfu:Sfum_2135 precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: A0LK65 Precorrin-2 C20-methyltransferase / cobalt-factor II C20-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase. | 0.903 |
| Deba_1636 | Deba_2460 | Deba_1636 | Deba_2460 | COGs: COG2875 Precorrin-4 methylase; InterPro IPR000878:IPR014777:IPR014776; KEGG: ppd:Ppro_1250 uroporphyrin-III C/tetrapyrrole methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: A1ANF1 Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases. | precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; COGs: COG2242 Precorrin-6B methylase 2; InterPro IPR012818:IPR014008:IPR000878:IPR006365; KEGG: dvl:Dvul_0558 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-6Y C(5,15)-methyltransferase (decarboxylating); SPTR: A1VAW5 Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit; TIGRFAM: precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; precorrin-6y C5,15-methyltransferase (d [...] | 0.960 |
| Deba_1636 | Deba_2462 | Deba_1636 | Deba_2462 | COGs: COG2875 Precorrin-4 methylase; InterPro IPR000878:IPR014777:IPR014776; KEGG: ppd:Ppro_1250 uroporphyrin-III C/tetrapyrrole methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: A1ANF1 Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases. | COGs: COG2073 Cobalamin biosynthesis protein CbiG; InterPro IPR002750; KEGG: dma:DMR_02540 cobalamin biosynthesis protein CbiG; PFAM: cobalamin (vitamin B12) biosynthesis CbiG protein; SPTR: C4XGG5 Cobalamin biosynthesis protein CbiG; PFAM: Cobalamin biosynthesis central region; Cobalamin synthesis G C-terminus; Cobalamin synthesis G N-terminal. | 0.933 |
| Deba_1636 | Deba_2463 | Deba_1636 | Deba_2463 | COGs: COG2875 Precorrin-4 methylase; InterPro IPR000878:IPR014777:IPR014776; KEGG: ppd:Ppro_1250 uroporphyrin-III C/tetrapyrrole methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: A1ANF1 Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases. | COGs: COG1010 Precorrin-3B methylase; InterPro IPR006363:IPR014777:IPR000878; KEGG: gtn:GTNG_1694 precorrin-3 methylase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-3B C(17)-methyltransferase; SPTR: A4IP04 Precorrin-3 methylase; TIGRFAM: precorrin-3B C17-methyltransferase; manually curated; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. | 0.954 |
| Deba_1636 | Deba_2958 | Deba_1636 | Deba_2958 | COGs: COG2875 Precorrin-4 methylase; InterPro IPR000878:IPR014777:IPR014776; KEGG: ppd:Ppro_1250 uroporphyrin-III C/tetrapyrrole methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: A1ANF1 Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases. | Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731:IPR013785; KEGG: dol:Dole_1224 delta-aminolevulinic acid dehydratase; PFAM: delta-aminolevulinic acid dehydratase; PRIAM: Porphobilinogen synthase; SPTR: A8ZY23 Delta-aminolevulinic acid dehydratase; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.840 |
| Deba_1636 | cbiD | Deba_1636 | Deba_2459 | COGs: COG2875 Precorrin-4 methylase; InterPro IPR000878:IPR014777:IPR014776; KEGG: ppd:Ppro_1250 uroporphyrin-III C/tetrapyrrole methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: A1ANF1 Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases. | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | 0.894 |
| Deba_1636 | cobQ | Deba_1636 | Deba_2679 | COGs: COG2875 Precorrin-4 methylase; InterPro IPR000878:IPR014777:IPR014776; KEGG: ppd:Ppro_1250 uroporphyrin-III C/tetrapyrrole methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: A1ANF1 Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.895 |
| Deba_1636 | hemC | Deba_1636 | Deba_0814 | COGs: COG2875 Precorrin-4 methylase; InterPro IPR000878:IPR014777:IPR014776; KEGG: ppd:Ppro_1250 uroporphyrin-III C/tetrapyrrole methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: A1ANF1 Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.865 |
| Deba_2457 | Deba_1636 | Deba_2457 | Deba_1636 | Precorrin-8X methylmutase; COGs: COG2082 Precorrin isomerase; InterPro IPR003722; KEGG: dba:Dbac_0965 precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase CbiC/CobH; PRIAM: Precorrin-8X methylmutase; SPTR: C0GRL7 Precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase. | COGs: COG2875 Precorrin-4 methylase; InterPro IPR000878:IPR014777:IPR014776; KEGG: ppd:Ppro_1250 uroporphyrin-III C/tetrapyrrole methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: A1ANF1 Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases. | 0.938 |
| Deba_2457 | Deba_2458 | Deba_2457 | Deba_2458 | Precorrin-8X methylmutase; COGs: COG2082 Precorrin isomerase; InterPro IPR003722; KEGG: dba:Dbac_0965 precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase CbiC/CobH; PRIAM: Precorrin-8X methylmutase; SPTR: C0GRL7 Precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase. | COGs: COG2243 Precorrin-2 methylase; InterPro IPR006364:IPR014777:IPR000878:IPR012382; KEGG: sfu:Sfum_2135 precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: A0LK65 Precorrin-2 C20-methyltransferase / cobalt-factor II C20-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase. | 0.994 |
| Deba_2457 | Deba_2460 | Deba_2457 | Deba_2460 | Precorrin-8X methylmutase; COGs: COG2082 Precorrin isomerase; InterPro IPR003722; KEGG: dba:Dbac_0965 precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase CbiC/CobH; PRIAM: Precorrin-8X methylmutase; SPTR: C0GRL7 Precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase. | precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; COGs: COG2242 Precorrin-6B methylase 2; InterPro IPR012818:IPR014008:IPR000878:IPR006365; KEGG: dvl:Dvul_0558 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-6Y C(5,15)-methyltransferase (decarboxylating); SPTR: A1VAW5 Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit; TIGRFAM: precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; precorrin-6y C5,15-methyltransferase (d [...] | 0.999 |
| Deba_2457 | Deba_2462 | Deba_2457 | Deba_2462 | Precorrin-8X methylmutase; COGs: COG2082 Precorrin isomerase; InterPro IPR003722; KEGG: dba:Dbac_0965 precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase CbiC/CobH; PRIAM: Precorrin-8X methylmutase; SPTR: C0GRL7 Precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase. | COGs: COG2073 Cobalamin biosynthesis protein CbiG; InterPro IPR002750; KEGG: dma:DMR_02540 cobalamin biosynthesis protein CbiG; PFAM: cobalamin (vitamin B12) biosynthesis CbiG protein; SPTR: C4XGG5 Cobalamin biosynthesis protein CbiG; PFAM: Cobalamin biosynthesis central region; Cobalamin synthesis G C-terminus; Cobalamin synthesis G N-terminal. | 0.993 |
| Deba_2457 | Deba_2463 | Deba_2457 | Deba_2463 | Precorrin-8X methylmutase; COGs: COG2082 Precorrin isomerase; InterPro IPR003722; KEGG: dba:Dbac_0965 precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase CbiC/CobH; PRIAM: Precorrin-8X methylmutase; SPTR: C0GRL7 Precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase. | COGs: COG1010 Precorrin-3B methylase; InterPro IPR006363:IPR014777:IPR000878; KEGG: gtn:GTNG_1694 precorrin-3 methylase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-3B C(17)-methyltransferase; SPTR: A4IP04 Precorrin-3 methylase; TIGRFAM: precorrin-3B C17-methyltransferase; manually curated; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. | 0.999 |