STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cas1-2CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (655 aa)    
Predicted Functional Partners:
cas2-2
CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
 
 0.986
cas2
CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
 
 0.940
Deba_0257
Methyltransferase FkbM family; InterPro IPR006342; KEGG: mlb:MLBr_02346 hypothetical protein; SPTR: B9YTU9 Methyltransferase FkbM family; TIGRFAM: methyltransferase FkbM family; TIGRFAM: methyltransferase, FkbM family.
  
 
 0.923
Deba_1693
KEGG: dau:Daud_1295 hypothetical protein; SPTR: A4BL60 Putative uncharacterized protein; PFAM: Uncharacterized conserved protein (DUF2276).
 
  
 0.880
Deba_1661
CRISPR-associated protein Cas4; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family.
 
 
 
 0.857
Deba_1352
Protein of unknown function DUF324; InterPro IPR005537; KEGG: syn:sll7066 hypothetical protein; PFAM: protein of unknown function DUF324; SPTR: Q6ZED2 Putative uncharacterized protein sll7066; PFAM: RAMP superfamily.
 
     0.589
Deba_1657
Metal dependent phosphohydrolase; COGs: COG1203 helicase; InterProIPR006675:IPR006474:IPR014001:IPR006674:IPR 014021; KEGG: dvm:DvMF_1971 CRISPR-associated helicase Cas3; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: DEAD-like helicase; SPTR: B8DQ50 CRISPR-associated helicase Cas3; TIGRFAM: CRISPR-associated helicase Cas3; metal dependent phophohydrolase; PFAM: HD domain; DEAD/DEAH box helicase; TIGRFAM: CRISPR-associated helicase Cas3; uncharacterized domain HDIG.
 
  
 0.537
Deba_1950
Transcriptional regulator, XRE family; InterPro IPR001387:IPR013096:IPR011051:IPR014710; KEGG: drt:Dret_1668 transcriptional regulator, XRE family; PFAM: Cupin 2 conserved barrel domain protein; helix-turn-helix domain protein; SMART: helix-turn-helix domain protein; SPTR: C8X3F5 Transcriptional regulator, XRE family; PFAM: Cupin domain; Helix-turn-helix.
   
 
 0.528
Deba_0072
Transcriptional modulator of MazE/toxin, MazF; COGs: COG2337 Growth inhibitor; InterPro IPR003477:IPR011067; KEGG: pph:Ppha_0265 transcriptional modulator of MazE/toxin, MazF; PFAM: PemK family protein; SPTR: B0BJH3 Putative integron gene cassette protein; PFAM: PemK-like protein.
 
   
 0.518
Deba_1695
KEGG: ana:alr0841 hypothetical protein; SPTR: B4W3A2 Putative uncharacterized protein.
 
     0.509
Your Current Organism:
Desulfarculus baarsii
NCBI taxonomy Id: 644282
Other names: D. baarsii DSM 2075, Desulfarculus baarsii 2st 14, Desulfarculus baarsii DSM 2075, Desulfarculus baarsii str. DSM 2075, Desulfarculus baarsii strain DSM 2075
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.