Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Deba_1832ERCC4 domain protein; COGs: COG1948 ERCC4-type nuclease; InterPro IPR006166:IPR011335:IPR020819; KEGG: sfu:Sfum_3788 ERCC4 domain-containing protein; PFAM: ERCC4 domain protein; SMART: ERCC4 domain protein; SPTR: C6MK29 ERCC4 domain protein. (160 aa)    
Predicted Functional Partners:
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 0.958
Deba_1834
KEGG: sfu:Sfum_3786 hypothetical protein; SPTR: A0LPV3 Putative uncharacterized protein.
 
     0.953
Deba_1830
DNA primase catalytic core domain protein; COGs: COG0358 DNA primase; InterPro IPR002694:IPR013264; KEGG: sfu:Sfum_3790 DNA primase catalytic core; PFAM: DNA primase catalytic core domain; SMART: zinc finger CHC2-family protein; SPTR: A0LPV7 DNA primase catalytic core, N-terminal domain; PFAM: DNA primase catalytic core, N-terminal domain; CHC2 zinc finger; TIGRFAM: DNA primase, catalytic core.
 
     0.950
Deba_1835
KEGG: sfu:Sfum_3785 hypothetical protein; SPTR: A0LPV2 Putative uncharacterized protein.
 
     0.939
Deba_1831
COGs: COG0507 ATP-dependent exoDNAse (exonuclease V) alpha subunit - helicase superfamily I member; KEGG: dde:Dde_1922 ATP-dependent RecD/TraA family DNA helicase; SPTR: C6MK30 ATP-dependent RecD/TraA family DNA helicase; TIGRFAM: helicase, putative, RecD/TraA family.
 
 
 
 0.932
Deba_0246
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
    
 0.902
Deba_1837
RNA polymerase, sigma-24 subunit, ECF subfamily; InterPro IPR018170:IPR014284; KEGG: dde:Dde_1928 sigma-24 (FecI-like); SPTR: C6MK24 RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70, region 4; Sigma-70 region 2; TIGRFAM: RNA polymerase sigma factor, sigma-70 family.
 
     0.893
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
    
 0.875
asnS
COGs: COG0017 Aspartyl/asparaginyl-tRNA synthetase; InterProIPR004365:IPR004364:IPR016027:IPR012340:IPR 002312:IPR004522:IPR006195; KEGG: dvu:DVU0007 asparaginyl-tRNA synthetase; PFAM: tRNA synthetase class II (D K and N); nucleic acid binding OB-fold tRNA/helicase-type; PRIAM: Asparagine--tRNA ligase; SPTR: C5TZ48 Asparaginyl-tRNA synthetase; TIGRFAM: asparaginyl-tRNA synthetase; PFAM: tRNA synthetases class II (D, K and N); OB-fold nucleic acid binding domain; TIGRFAM: asparaginyl-tRNA synthetase.
  
 0.864
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
   
 0.856
Your Current Organism:
Desulfarculus baarsii
NCBI taxonomy Id: 644282
Other names: D. baarsii DSM 2075, Desulfarculus baarsii 2st 14, Desulfarculus baarsii DSM 2075, Desulfarculus baarsii str. DSM 2075, Desulfarculus baarsii strain DSM 2075
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