STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
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[Homology]
Score
recD2Helicase, RecD/TraA family; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (720 aa)    
Predicted Functional Partners:
Deba_1854
UvrD/REP helicase; COGs: COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains); InterPro IPR000212:IPR014016:IPR014017; KEGG: acp:A2cp1_1439 UvrD/REP helicase; PFAM: UvrD/REP helicase; SPTR: B8JH81 UvrD/REP helicase; PFAM: UvrD/REP helicase; Belongs to the helicase family. UvrD subfamily.
  
 
 0.986
Deba_1831
COGs: COG0507 ATP-dependent exoDNAse (exonuclease V) alpha subunit - helicase superfamily I member; KEGG: dde:Dde_1922 ATP-dependent RecD/TraA family DNA helicase; SPTR: C6MK30 ATP-dependent RecD/TraA family DNA helicase; TIGRFAM: helicase, putative, RecD/TraA family.
  
  
 
0.921
Deba_1855
COGs: COG3857 ATP-dependent nuclease subunit B; KEGG: ade:Adeh_2513 ATP-dependent nuclease subunit B-like; SPTR: Q2IKV6 ATP-dependent nuclease subunit B-like.
     
 0.810
Deba_0246
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 
 0.798
aroK
Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
       0.780
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 
 0.654
Deba_3097
Tetratricopeptide TPR_2 repeat protein; InterProIPR001440:IPR013105:IPR019734:IPR013026:IPR 011990; KEGG: dat:HRM2_20780 tetratricopeptide (TPR) domain protein; PFAM: Tetratricopeptide TPR_2 repeat protein; TPR repeat-containing protein; SPTR: C0QDB3 Tetratricopeptide (TPR) domain protein; PFAM: ChAPs (Chs5p-Arf1p-binding proteins); TIGRFAM: putative PEP-CTERM system TPR-repeat lipoprotein.
  
 
 0.614
Deba_0816
UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR014016:IPR014017:IPR000212; KEGG: dma:DMR_07030 ATP-dependent DNA helicase; PFAM: UvrD/REP helicase; SPTR: Q1NUA0 UvrD/REP helicase; PFAM: UvrD/REP helicase.
  
 
 0.604
Deba_2185
UvrD/REP helicase; COGs: COG1379 conserved hypothetical protein; InterPro IPR014016:IPR014017:IPR000212; KEGG: rmr:Rmar_0317 UvrD/REP helicase; PFAM: UvrD/REP helicase; SPTR: D0MDM9 UvrD/REP helicase; PFAM: UvrD/REP helicase; TIGRFAM: conserved hypothetical protein TIGR00375.
  
 
 0.594
Deba_2577
Helicase domain protein; COGs: COG0553 Superfamily II DNA/RNA helicase SNF2 family; InterPro IPR014001:IPR001650:IPR000330:IPR014021; KEGG: sfu:Sfum_3846 helicase domain-containing protein; PFAM: helicase domain protein; SNF2-related protein; SMART: DEAD-like helicase; helicase domain protein; SPTR: A0LQ13 Helicase domain protein; manually curated; PFAM: Helicase conserved C-terminal domain; SNF2 family N-terminal domain.
  
 
 0.592
Your Current Organism:
Desulfarculus baarsii
NCBI taxonomy Id: 644282
Other names: D. baarsii DSM 2075, Desulfarculus baarsii 2st 14, Desulfarculus baarsii DSM 2075, Desulfarculus baarsii str. DSM 2075, Desulfarculus baarsii strain DSM 2075
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