STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Deba_1897RNA polymerase, sigma 32 subunit, RpoH; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (346 aa)    
Predicted Functional Partners:
rpoZ
DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
 
 
 
 0.935
rpoB
DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
 
 
 0.917
rpoA
DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
 
 
 0.905
Deba_0731
COGs: COG1329 Transcriptional regulators similar to M. xanthus CarD; InterPro IPR003711; KEGG: dal:Dalk_3372 transcriptional regulator, CarD family; PFAM: transcription factor CarD; SPTR: B8FLB5 Transcriptional regulator, CarD family; PFAM: CarD-like/TRCF domain.
 
 
 
 0.863
rpoC
DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
 
 
 0.862
nusA
Transcription termination factor NusA; Participates in both transcription termination and antitermination.
 
 
 0.842
groL
Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
 
 0.825
Deba_0503
Diguanylate cyclase/phosphodiesterase; COGs: COG2200 FOG: EAL domain; InterPro IPR001633:IPR000644:IPR000160; KEGG: drt:Dret_0176 diguanylate cyclase/phosphodiesterase; PFAM: EAL domain protein; CBS domain containing protein; GGDEF domain containing protein; SMART: EAL domain protein; GGDEF domain containing protein; SPTR: C8WZK3 Diguanylate cyclase/phosphodiesterase; TIGRFAM: diguanylate cyclase; PFAM: EAL domain; CBS domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain.
   
 
 0.817
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
  
 
 0.810
Deba_1896
Tetratricopeptide TPR_2 repeat protein; COGs: COG3063 Tfp pilus assembly protein PilF; InterProIPR019734:IPR013105:IPR001440:IPR011717:IPR 013026:IPR011990; KEGG: sfu:Sfum_0074 TPR repeat-containing protein; PFAM: Tetratricopeptide TPR_2 repeat protein; TPR repeat-containing protein; Tetratricopeptide TPR_4; SMART: Tetratricopeptide repeat; SPTR: A0LEC5 TPR repeat-containing protein; PFAM: Tetratricopeptide repeat.
  
  
 0.755
Your Current Organism:
Desulfarculus baarsii
NCBI taxonomy Id: 644282
Other names: D. baarsii DSM 2075, Desulfarculus baarsii 2st 14, Desulfarculus baarsii DSM 2075, Desulfarculus baarsii str. DSM 2075, Desulfarculus baarsii strain DSM 2075
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