STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Deba_2149COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: dal:Dalk_3267 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: B8FJ30 Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (290 aa)    
Predicted Functional Partners:
Deba_2153
COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: dal:Dalk_2779 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: B8FKU9 Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
 
  
 
0.963
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.943
fhs
Formate--tetrahydrofolate ligase; COGs: COG2759 Formyltetrahydrofolate synthetase; InterPro IPR020628:IPR000559; KEGG: dat:HRM2_16700 Fhs; PFAM: formate-tetrahydrofolate ligase FTHFS; PRIAM: Formate--tetrahydrofolate ligase; SPTR: C0QAX9 Formate--tetrahydrofolate ligase; PFAM: Formate--tetrahydrofolate ligase.
  
 
 0.923
folD
Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.919
Deba_2224
COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: dol:Dole_0458 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: A8ZTK4 Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
 
  
 
0.918
Deba_2152
KEGG: dal:Dalk_3264 hypothetical protein; SPTR: B8FJ27 Putative uncharacterized protein; PFAM: Methylene-tetrahydrofolate reductase C terminal.
 
  
 0.914
Deba_1514
Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
     
 0.908
Deba_2205
KEGG: deb:DehaBAV1_0492 hypothetical protein; SPTR: A5FRU6 Putative uncharacterized protein; PFAM: Cobalamin-independent synthase, Catalytic domain.
  
 
 0.816
Deba_2225
KEGG: dat:HRM2_30870 putative zinc-finger protein; SPTR: C0QKT0 Putative zinc-finger protein; PFAM: Methylene-tetrahydrofolate reductase C terminal.
 
  
 0.799
Deba_0238
Dihydropteroate synthase DHPS; COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR000489:IPR011005; KEGG: dol:Dole_3182 dihydropteroate synthase DhpS; PFAM: dihydropteroate synthase DHPS; SPTR: A9A066 Dihydropteroate synthase DHPS; PFAM: Pterin binding enzyme.
 
  
 0.796
Your Current Organism:
Desulfarculus baarsii
NCBI taxonomy Id: 644282
Other names: D. baarsii DSM 2075, Desulfarculus baarsii 2st 14, Desulfarculus baarsii DSM 2075, Desulfarculus baarsii str. DSM 2075, Desulfarculus baarsii strain DSM 2075
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