STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
Deba_2202Maf protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (200 aa)    
Predicted Functional Partners:
Deba_2203
Alanine racemase domain protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
    0.945
Deba_3154
Methyltransferase type 12; InterPro IPR013217; KEGG: gsu:GSU1214 tetracenomycin polyketide synthesis 8-O-methyltransferase, putative; PFAM: Methyltransferase type 12; SPTR: Q74DV1 Tetracenomycin polyketide synthesis 8-o-methyltransferase, putative; PFAM: O-methyltransferase.
 
    0.904
Deba_2897
COGs: COG2003 DNA repair protein; InterPro IPR001405; KEGG: dol:Dole_0675 DNA repair protein RadC; PFAM: DNA repair protein RadC; SPTR: A8ZUS2 DNA repair protein RadC; TIGRFAM: DNA repair protein RadC; PFAM: Protein of unknown function (DUF2466); TIGRFAM: DNA repair protein radc; Belongs to the UPF0758 family.
  
  
 0.840
Deba_2201
Hydrolase, TatD family; COGs: COG0084 Mg-dependent DNase; InterPro IPR018228:IPR012278:IPR001130:IPR015991; KEGG: pca:Pcar_1695 Mg-dependent DNase; PFAM: TatD-related deoxyribonuclease; SPTR: Q3A3W9 Mg-dependent DNase; TIGRFAM: hydrolase, TatD family; PFAM: TatD related DNase; TIGRFAM: hydrolase, TatD family.
       0.795
Deba_0278
Rod shape-determining protein MreC; Involved in formation and maintenance of cell shape.
  
  
 0.709
Deba_1129
Oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family.
 
   
 0.560
ispDF
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).
 
     0.527
Deba_1166
Dihydrouridine synthase DuS; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family.
 
     0.521
Deba_0479
COGs: COG0077 Prephenate dehydratase; InterProIPR020822:IPR001086:IPR002912:IPR008242:IPR 002701:IPR018528; KEGG: pca:Pcar_1887 chorismate mutase-P and prephenate dehydratase; PFAM: prephenate dehydratase; Chorismate mutase, type II; amino acid-binding ACT domain protein; SPTR: Q1K0T9 Chorismate mutase; PFAM: Prephenate dehydratase; ACT domain; Chorismate mutase type II.
     
 0.513
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
       0.499
Your Current Organism:
Desulfarculus baarsii
NCBI taxonomy Id: 644282
Other names: D. baarsii DSM 2075, Desulfarculus baarsii 2st 14, Desulfarculus baarsii DSM 2075, Desulfarculus baarsii str. DSM 2075, Desulfarculus baarsii strain DSM 2075
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