STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mqnDProtein of unknown function DUF191; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily. (278 aa)    
Predicted Functional Partners:
mqnC
Radical SAM domain protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).
 
  
 0.983
Deba_2375
Futalosine nucleosidase; COGs: COG0775 Nucleoside phosphorylase; InterPro IPR000845:IPR019963; KEGG: gme:Gmet_3381 purine phosphorylase family protein 1; PFAM: purine or other phosphorylase family 1; SPTR: Q39Q81 Purine and other phosphorylases, family 1; TIGRFAM: futalosine nucleosidase; PFAM: Phosphorylase superfamily; TIGRFAM: futalosine nucleosidase.
 
   
 0.905
mqnA
Protein of unknown function DUF178; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
 
   
 0.871
mqnE
Radical SAM domain protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.
 
   
 0.816
Deba_1158
COGs: COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferase; InterPro IPR000537:IPR006371; KEGG: sfu:Sfum_0288 4-hydroxybenzoate polyprenyltransferase, putative; PFAM: UbiA prenyltransferase; SPTR: A0LEY7 4-hydroxybenzoate polyprenyltransferase, putative; TIGRFAM: 4-hydroxybenzoate polyprenyltransferase; PFAM: UbiA prenyltransferase family; TIGRFAM: putative 4-hydroxybenzoate polyprenyltransferase; Belongs to the UbiA prenyltransferase family.
 
   
 0.799
Deba_2376
Transcriptional regulator, TetR family; InterPro IPR009057:IPR011075:IPR001647:IPR012287; KEGG: sfu:Sfum_3090 TetR family transcriptional regulator; PFAM: regulatory protein TetR; SPTR: A0LMW1 Transcriptional regulator, TetR family; PFAM: Bacterial regulatory proteins, tetR family.
       0.790
nusB
NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
       0.773
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
       0.773
ribBA
GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
       0.767
Deba_2380
GCN5-related N-acetyltransferase; InterPro IPR016181:IPR000182; KEGG: dda:Dd703_2189 transcriptional regulator, MarR family with acetyltransferase activity; PFAM: GCN5-related N-acetyltransferase; SPTR: C6C7N4 Transcriptional regulator, MarR family with acetyltransferase activity; PFAM: Acetyltransferase (GNAT) family.
       0.625
Your Current Organism:
Desulfarculus baarsii
NCBI taxonomy Id: 644282
Other names: D. baarsii DSM 2075, Desulfarculus baarsii 2st 14, Desulfarculus baarsii DSM 2075, Desulfarculus baarsii str. DSM 2075, Desulfarculus baarsii strain DSM 2075
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