STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Deba_2422Sodium/hydrogen exchanger; COGs: COG0475 Kef-type K+ transport systems membrane components; InterPro IPR014729:IPR006153:IPR006016; KEGG: aoe:Clos_2091 sodium/hydrogen exchanger; PFAM: sodium/hydrogen exchanger; UspA domain protein; SPTR: A8MIJ5 Sodium/hydrogen exchanger; PFAM: Universal stress protein family; Sodium/hydrogen exchanger family. (710 aa)    
Predicted Functional Partners:
Deba_2421
Oxidoreductase domain protein; COGs: COG0673 dehydrogenase and related protein; InterPro IPR016040:IPR011004:IPR000683:IPR001451; KEGG: cbc:CbuK_0696 NAD-dependent oxidoreductase; PFAM: oxidoreductase domain protein; transferase hexapeptide repeat containing protein; SPTR: B6J6Q3 NAD-dependent oxidoreductase; PFAM: Oxidoreductase family, NAD-binding Rossmann fold; Bacterial transferase hexapeptide (three repeats).
       0.727
Deba_0532
NAD(P)H dehydrogenase (quinone); COGs: COG2249 Putative NADPH-quinone reductase (modulator of drug activity B); InterPro IPR003680; KEGG: ank:AnaeK_0029 NAD(P)H dehydrogenase (quinone); PFAM: NAD(P)H dehydrogenase (quinone); SPTR: B4UKI1 NAD(P)H dehydrogenase (Quinone); PFAM: Flavodoxin-like fold.
  
 
 0.630
Deba_0023
Sodium/hydrogen exchanger; COGs: COG4651 Kef-type K+ transport system predicted NAD-binding component; InterPro IPR006153:IPR003148:IPR006037:IPR016040; KEGG: dvm:DvMF_1119 sodium/hydrogen exchanger; PFAM: sodium/hydrogen exchanger; TrkA-N domain protein; TrkA-C domain protein; SPTR: B8DKB1 Sodium/hydrogen exchanger; PFAM: TrkA-N domain; TrkA-C domain; Sodium/hydrogen exchanger family; TIGRFAM: potassium efflux system protein; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.
     
 0.555
Deba_1290
COGs: COG0642 Signal transduction histidine kinase; InterProIPR001789:IPR013767:IPR003018:IPR013656:IPR 003661:IPR003594:IPR008207:IPR005467:IPR000014:IPR000700:I PR004358:IPR001610:IPR011006:IPR009082; KEGG: dvm:DvMF_1096 multi-sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; response regulator receiver; PAS fold domain protein; GAF domain protein; PAS fold-4 domain protein; Hpt domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; response regulator receiver; PAS domain con [...]
 
   
 0.554
Deba_0587
Cl- channel voltage-gated family protein; COGs: COG0038 Chloride channel protein EriC; InterPro IPR001807:IPR000644:IPR014743; KEGG: sfu:Sfum_2352 Cl-channel, voltage-gated family protein; PFAM: Cl- channel voltage-gated family protein; CBS domain containing protein; SMART: CBS domain containing protein; SPTR: A0LKT1 Cl-channel, voltage-gated family protein; PFAM: CBS domain; Voltage gated chloride channel.
 
   
 0.532
Deba_1258
COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterProIPR015590:IPR001670:IPR018211:IPR016160:IPR 016162:IPR016161; KEGG: dal:Dalk_3586 aldehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; iron-containing alcohol dehydrogenase; SPTR: B8FGP4 Aldehyde Dehydrogenase; PFAM: Aldehyde dehydrogenase family; Iron-containing alcohol dehydrogenase.
  
  
 0.528
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
 
   
 0.500
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.498
Deba_2420
COGs: COG3894 Uncharacterized metal-binding protein; KEGG: dol:Dole_1485 iron-sulfur cluster binding protein; SPTR: Q1NV39 Iron-sulfur cluster binding protein.
       0.459
Deba_2144
COGs: COG0777 Acetyl-CoA carboxylase beta subunit; InterPro IPR000438:IPR011762:IPR011763:IPR000022; KEGG: gsu:GSU2370 acetyl-CoA carboxylase, carboxyl transferase, beta subunit; PFAM: carboxyl transferase; SPTR: Q74AI4 Acetyl-CoA carboxylase, carboxyl transferase, beta subunit; PFAM: Carboxyl transferase domain; TIGRFAM: acetyl-CoA carboxylase, carboxyl transferase, beta subunit.
     
 0.437
Your Current Organism:
Desulfarculus baarsii
NCBI taxonomy Id: 644282
Other names: D. baarsii DSM 2075, Desulfarculus baarsii 2st 14, Desulfarculus baarsii DSM 2075, Desulfarculus baarsii str. DSM 2075, Desulfarculus baarsii strain DSM 2075
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.