| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Deba_0329 | Deba_2458 | Deba_0329 | Deba_2458 | COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR016040:IPR006367; KEGG: sfu:Sfum_1588 siroheme synthase; SPTR: A0LIM3 Precorrin-2 dehydrogenase; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain. | COGs: COG2243 Precorrin-2 methylase; InterPro IPR006364:IPR014777:IPR000878:IPR012382; KEGG: sfu:Sfum_2135 precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: A0LK65 Precorrin-2 C20-methyltransferase / cobalt-factor II C20-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase. | 0.927 |
| Deba_0329 | Deba_2460 | Deba_0329 | Deba_2460 | COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR016040:IPR006367; KEGG: sfu:Sfum_1588 siroheme synthase; SPTR: A0LIM3 Precorrin-2 dehydrogenase; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain. | precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; COGs: COG2242 Precorrin-6B methylase 2; InterPro IPR012818:IPR014008:IPR000878:IPR006365; KEGG: dvl:Dvul_0558 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-6Y C(5,15)-methyltransferase (decarboxylating); SPTR: A1VAW5 Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit; TIGRFAM: precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; precorrin-6y C5,15-methyltransferase (d [...] | 0.647 |
| Deba_0329 | Deba_2461 | Deba_0329 | Deba_2461 | COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR016040:IPR006367; KEGG: sfu:Sfum_1588 siroheme synthase; SPTR: A0LIM3 Precorrin-2 dehydrogenase; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain. | COGs: COG2875 Precorrin-4 methylase; InterProIPR006362:IPR003043:IPR014777:IPR014776:IPR 000878; KEGG: dat:HRM2_02280 CobM; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-4 C(11)-methyltransferase; SPTR: C0GRK4 Precorrin-4 C11-methyltransferase; TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.938 |
| Deba_0329 | Deba_2464 | Deba_0329 | Deba_2464 | COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR016040:IPR006367; KEGG: sfu:Sfum_1588 siroheme synthase; SPTR: A0LIM3 Precorrin-2 dehydrogenase; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain. | Anaerobic cobalt chelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin. Belongs to the CbiK family. | 0.915 |
| Deba_0329 | Deba_2752 | Deba_0329 | Deba_2752 | COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR016040:IPR006367; KEGG: sfu:Sfum_1588 siroheme synthase; SPTR: A0LIM3 Precorrin-2 dehydrogenase; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain. | Anaerobic cobalt chelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin. Belongs to the CbiK family. | 0.915 |
| Deba_2457 | Deba_2458 | Deba_2457 | Deba_2458 | Precorrin-8X methylmutase; COGs: COG2082 Precorrin isomerase; InterPro IPR003722; KEGG: dba:Dbac_0965 precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase CbiC/CobH; PRIAM: Precorrin-8X methylmutase; SPTR: C0GRL7 Precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase. | COGs: COG2243 Precorrin-2 methylase; InterPro IPR006364:IPR014777:IPR000878:IPR012382; KEGG: sfu:Sfum_2135 precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: A0LK65 Precorrin-2 C20-methyltransferase / cobalt-factor II C20-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase. | 0.992 |
| Deba_2457 | Deba_2460 | Deba_2457 | Deba_2460 | Precorrin-8X methylmutase; COGs: COG2082 Precorrin isomerase; InterPro IPR003722; KEGG: dba:Dbac_0965 precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase CbiC/CobH; PRIAM: Precorrin-8X methylmutase; SPTR: C0GRL7 Precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase. | precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; COGs: COG2242 Precorrin-6B methylase 2; InterPro IPR012818:IPR014008:IPR000878:IPR006365; KEGG: dvl:Dvul_0558 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-6Y C(5,15)-methyltransferase (decarboxylating); SPTR: A1VAW5 Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit; TIGRFAM: precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; precorrin-6y C5,15-methyltransferase (d [...] | 0.999 |
| Deba_2457 | Deba_2461 | Deba_2457 | Deba_2461 | Precorrin-8X methylmutase; COGs: COG2082 Precorrin isomerase; InterPro IPR003722; KEGG: dba:Dbac_0965 precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase CbiC/CobH; PRIAM: Precorrin-8X methylmutase; SPTR: C0GRL7 Precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase. | COGs: COG2875 Precorrin-4 methylase; InterProIPR006362:IPR003043:IPR014777:IPR014776:IPR 000878; KEGG: dat:HRM2_02280 CobM; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-4 C(11)-methyltransferase; SPTR: C0GRK4 Precorrin-4 C11-methyltransferase; TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.988 |
| Deba_2457 | Deba_2462 | Deba_2457 | Deba_2462 | Precorrin-8X methylmutase; COGs: COG2082 Precorrin isomerase; InterPro IPR003722; KEGG: dba:Dbac_0965 precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase CbiC/CobH; PRIAM: Precorrin-8X methylmutase; SPTR: C0GRL7 Precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase. | COGs: COG2073 Cobalamin biosynthesis protein CbiG; InterPro IPR002750; KEGG: dma:DMR_02540 cobalamin biosynthesis protein CbiG; PFAM: cobalamin (vitamin B12) biosynthesis CbiG protein; SPTR: C4XGG5 Cobalamin biosynthesis protein CbiG; PFAM: Cobalamin biosynthesis central region; Cobalamin synthesis G C-terminus; Cobalamin synthesis G N-terminal. | 0.991 |
| Deba_2457 | Deba_2463 | Deba_2457 | Deba_2463 | Precorrin-8X methylmutase; COGs: COG2082 Precorrin isomerase; InterPro IPR003722; KEGG: dba:Dbac_0965 precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase CbiC/CobH; PRIAM: Precorrin-8X methylmutase; SPTR: C0GRL7 Precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase. | COGs: COG1010 Precorrin-3B methylase; InterPro IPR006363:IPR014777:IPR000878; KEGG: gtn:GTNG_1694 precorrin-3 methylase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-3B C(17)-methyltransferase; SPTR: A4IP04 Precorrin-3 methylase; TIGRFAM: precorrin-3B C17-methyltransferase; manually curated; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. | 0.998 |
| Deba_2457 | Deba_2464 | Deba_2457 | Deba_2464 | Precorrin-8X methylmutase; COGs: COG2082 Precorrin isomerase; InterPro IPR003722; KEGG: dba:Dbac_0965 precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase CbiC/CobH; PRIAM: Precorrin-8X methylmutase; SPTR: C0GRL7 Precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase. | Anaerobic cobalt chelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin. Belongs to the CbiK family. | 0.950 |
| Deba_2457 | Deba_2752 | Deba_2457 | Deba_2752 | Precorrin-8X methylmutase; COGs: COG2082 Precorrin isomerase; InterPro IPR003722; KEGG: dba:Dbac_0965 precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase CbiC/CobH; PRIAM: Precorrin-8X methylmutase; SPTR: C0GRL7 Precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase. | Anaerobic cobalt chelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin. Belongs to the CbiK family. | 0.815 |
| Deba_2457 | cbiA-2 | Deba_2457 | Deba_2456 | Precorrin-8X methylmutase; COGs: COG2082 Precorrin isomerase; InterPro IPR003722; KEGG: dba:Dbac_0965 precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase CbiC/CobH; PRIAM: Precorrin-8X methylmutase; SPTR: C0GRL7 Precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.998 |
| Deba_2457 | cbiD | Deba_2457 | Deba_2459 | Precorrin-8X methylmutase; COGs: COG2082 Precorrin isomerase; InterPro IPR003722; KEGG: dba:Dbac_0965 precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase CbiC/CobH; PRIAM: Precorrin-8X methylmutase; SPTR: C0GRL7 Precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase. | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | 0.990 |
| Deba_2458 | Deba_0329 | Deba_2458 | Deba_0329 | COGs: COG2243 Precorrin-2 methylase; InterPro IPR006364:IPR014777:IPR000878:IPR012382; KEGG: sfu:Sfum_2135 precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: A0LK65 Precorrin-2 C20-methyltransferase / cobalt-factor II C20-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase. | COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR016040:IPR006367; KEGG: sfu:Sfum_1588 siroheme synthase; SPTR: A0LIM3 Precorrin-2 dehydrogenase; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain. | 0.927 |
| Deba_2458 | Deba_2457 | Deba_2458 | Deba_2457 | COGs: COG2243 Precorrin-2 methylase; InterPro IPR006364:IPR014777:IPR000878:IPR012382; KEGG: sfu:Sfum_2135 precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: A0LK65 Precorrin-2 C20-methyltransferase / cobalt-factor II C20-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase. | Precorrin-8X methylmutase; COGs: COG2082 Precorrin isomerase; InterPro IPR003722; KEGG: dba:Dbac_0965 precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase CbiC/CobH; PRIAM: Precorrin-8X methylmutase; SPTR: C0GRL7 Precorrin-8X methylmutase CbiC/CobH; PFAM: Precorrin-8X methylmutase. | 0.992 |
| Deba_2458 | Deba_2460 | Deba_2458 | Deba_2460 | COGs: COG2243 Precorrin-2 methylase; InterPro IPR006364:IPR014777:IPR000878:IPR012382; KEGG: sfu:Sfum_2135 precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: A0LK65 Precorrin-2 C20-methyltransferase / cobalt-factor II C20-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase. | precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; COGs: COG2242 Precorrin-6B methylase 2; InterPro IPR012818:IPR014008:IPR000878:IPR006365; KEGG: dvl:Dvul_0558 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-6Y C(5,15)-methyltransferase (decarboxylating); SPTR: A1VAW5 Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit; TIGRFAM: precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; precorrin-6y C5,15-methyltransferase (d [...] | 0.995 |
| Deba_2458 | Deba_2461 | Deba_2458 | Deba_2461 | COGs: COG2243 Precorrin-2 methylase; InterPro IPR006364:IPR014777:IPR000878:IPR012382; KEGG: sfu:Sfum_2135 precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: A0LK65 Precorrin-2 C20-methyltransferase / cobalt-factor II C20-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase. | COGs: COG2875 Precorrin-4 methylase; InterProIPR006362:IPR003043:IPR014777:IPR014776:IPR 000878; KEGG: dat:HRM2_02280 CobM; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-4 C(11)-methyltransferase; SPTR: C0GRK4 Precorrin-4 C11-methyltransferase; TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.989 |
| Deba_2458 | Deba_2462 | Deba_2458 | Deba_2462 | COGs: COG2243 Precorrin-2 methylase; InterPro IPR006364:IPR014777:IPR000878:IPR012382; KEGG: sfu:Sfum_2135 precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: A0LK65 Precorrin-2 C20-methyltransferase / cobalt-factor II C20-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase. | COGs: COG2073 Cobalamin biosynthesis protein CbiG; InterPro IPR002750; KEGG: dma:DMR_02540 cobalamin biosynthesis protein CbiG; PFAM: cobalamin (vitamin B12) biosynthesis CbiG protein; SPTR: C4XGG5 Cobalamin biosynthesis protein CbiG; PFAM: Cobalamin biosynthesis central region; Cobalamin synthesis G C-terminus; Cobalamin synthesis G N-terminal. | 0.995 |
| Deba_2458 | Deba_2463 | Deba_2458 | Deba_2463 | COGs: COG2243 Precorrin-2 methylase; InterPro IPR006364:IPR014777:IPR000878:IPR012382; KEGG: sfu:Sfum_2135 precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: A0LK65 Precorrin-2 C20-methyltransferase / cobalt-factor II C20-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase. | COGs: COG1010 Precorrin-3B methylase; InterPro IPR006363:IPR014777:IPR000878; KEGG: gtn:GTNG_1694 precorrin-3 methylase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-3B C(17)-methyltransferase; SPTR: A4IP04 Precorrin-3 methylase; TIGRFAM: precorrin-3B C17-methyltransferase; manually curated; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. | 0.998 |