STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Deba_2740Hydrogenase expression/formation protein HypD; COGs: COG0409 Hydrogenase maturation factor; InterPro IPR002780; KEGG: glo:Glov_3063 hydrogenase expression/formation protein HypD; PFAM: hydrogenase formation HypD protein; SPTR: B6G9X3 Putative uncharacterized protein; TIGRFAM: hydrogenase expression/formation protein HypD; PFAM: Hydrogenase formation hypA family; TIGRFAM: hydrogenase expression/formation protein HypD; Belongs to the HypD family. (361 aa)    
Predicted Functional Partners:
Deba_2739
Hydrogenase expression/formation protein HypE; COGs: COG0309 Hydrogenase maturation factor; InterPro IPR000728:IPR010918:IPR011854:IPR016188; KEGG: dma:DMR_20380 hydrogenase formation protein HypE; PFAM: AIR synthase related protein domain protein; AIR synthase related protein; SPTR: C4XRI4 Hydrogenase formation protein HypE; TIGRFAM: hydrogenase expression/formation protein HypE; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: hydrogenase expression/formation protein HypE.
 
 
 0.999
Deba_1403
Hydrogenase assembly chaperone hypC/hupF; COGs: COG0298 Hydrogenase maturation factor; InterPro IPR001109; KEGG: dal:Dalk_2278 hydrogenase assembly chaperone HypC/HupF; PFAM: hydrogenase expression/formation protein (HUPF/HYPC); SPTR: B8FII1 Hydrogenase assembly chaperone hypC/hupF; TIGRFAM: hydrogenase assembly chaperone hypC/hupF; PFAM: HupF/HypC family; TIGRFAM: hydrogenase assembly chaperone HypC/HupF.
 
 
 0.996
Deba_2742
Hydrogenase accessory protein HypB; COGs: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; InterPro IPR003495:IPR012202:IPR004392; KEGG: dvl:Dvul_0929 hydrogenase accessory protein HypB; PFAM: cobalamin synthesis protein P47K; SPTR: Q729M1 Hydrogenase accessory protein HypB; TIGRFAM: hydrogenase accessory protein HypB; PFAM: CobW/HypB/UreG, nucleotide-binding domain; TIGRFAM: hydrogenase accessory protein HypB.
 
  
 0.982
Deba_2741
(NiFe) hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
  
 0.975
hypA
Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
  
 0.958
Deba_0998
COGs: COG0374 Ni Fe-hydrogenase I large subunit; InterPro IPR001501:IPR018194; KEGG: dps:DP0159 cytochrome-c3 hydrogenase (NiFeSe), large subunit; PFAM: nickel-dependent hydrogenase large subunit; PRIAM: Cytochrome-c3 hydrogenase; SPTR: Q6ARY7 Related to cytochrome-c3 hydrogenase (NiFeSe), large subunit; PFAM: Nickel-dependent hydrogenase.
 
 
 0.832
Deba_1401
COGs: COG0374 Ni Fe-hydrogenase I large subunit; InterPro IPR001501:IPR018194; KEGG: dal:Dalk_2276 nickel-dependent hydrogenase large subunit; PFAM: nickel-dependent hydrogenase large subunit; SPTR: B8FIH9 Nickel-dependent hydrogenase large subunit; PFAM: Nickel-dependent hydrogenase; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 0.755
Deba_1195
Cobalamin synthesis protein P47K; COGs: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; InterPro IPR003495:IPR012202; KEGG: ppd:Ppro_0345 cobalamin synthesis protein, P47K; PFAM: cobalamin synthesis protein P47K; SPTR: A1AKV9 Cobalamin synthesis protein, P47K; PFAM: CobW/HypB/UreG, nucleotide-binding domain.
  
  
 0.726
Deba_0997
COGs: COG1740 Ni Fe-hydrogenase I small subunit; InterProIPR001821:IPR019546:IPR006137:IPR016160:IPR 017909:IPR006311; KEGG: dps:DP0160 periplasmic [NiFeSe] hydrogenase, small subunit [precursor]; PFAM: NADH ubiquinone oxidoreductase 20 kDa subunit; Twin-arginine translocation pathway, signal sequence, subgroup; PRIAM: Hydrogenase (acceptor); SPTR: Q6ARY6 Related to periplasmic [NiFeSe] hydrogenase, small subunit [Precursor]; TIGRFAM: hydrogenase (NiFe) small subunit HydA; PFAM: NADH ubiquinone oxidoreductase, 20 Kd subunit; TIGRFAM: Tat (twin-arginine translocation) pathway signal seq [...]
 
  
 0.668
Deba_1402
COGs: COG0680 Ni Fe-hydrogenase maturation factor; InterPro IPR000671; KEGG: sfu:Sfum_2951 hydrogenase expression/formation protein; PFAM: peptidase M52 hydrogen uptake protein; SPTR: A0LMH3 Hydrogenase expression/formation protein; TIGRFAM: hydrogenase maturation protease; PFAM: Hydrogenase maturation protease; TIGRFAM: hydrogenase expression/formation protein; hydrogenase maturation protease.
 
   
 0.603
Your Current Organism:
Desulfarculus baarsii
NCBI taxonomy Id: 644282
Other names: D. baarsii DSM 2075, Desulfarculus baarsii 2st 14, Desulfarculus baarsii DSM 2075, Desulfarculus baarsii str. DSM 2075, Desulfarculus baarsii strain DSM 2075
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.