STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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[Homology]
Score
Deba_2986COGs: COG0095 Lipoate-protein ligase A; InterPro IPR004143:IPR000923; KEGG: tro:trd_0142 hypothetical protein; PFAM: biotin/lipoate A/B protein ligase; SPTR: A8UQP5 Putative uncharacterized protein; PFAM: Bacterial lipoate protein ligase C-terminus; Biotin/lipoate A/B protein ligase family. (348 aa)    
Predicted Functional Partners:
lipB-2
Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives; Belongs to the LipB family.
 
 0.988
gcvH-2
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 
 0.955
Deba_3039
COGs: COG0095 Lipoate-protein ligase A; InterPro IPR004143:IPR002829; KEGG: mta:Moth_0443 biotin/lipoate A/B protein ligase; PFAM: biotin/lipoate A/B protein ligase; protein of unknown function DUF116; SPTR: Q2RLB5 Biotin/lipoate A/B protein ligase; PFAM: Protein of unknown function DUF116; Biotin/lipoate A/B protein ligase family; TIGRFAM: lipoyltransferase and lipoate-protein ligase.
  
  
 
0.927
Deba_2980
Catalytic domain of components of various dehydrogenase complexes; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterProIPR000089:IPR004167:IPR001078:IPR011053:IPR 003016; KEGG: rha:RHA1_ro11029 dihydrolipoyllysine-residue succinyltransferase; PFAM: catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; biotin/lipoyl attachment domain-containing protein; SPTR: Q0RVL0 Dihydrolipoyllysine-residue succinyltransferase; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); e3 bi [...]
 
 0.924
Deba_2981
COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterProIPR013027:IPR004099:IPR000815:IPR016156:IPR 012999:IPR006258; KEGG: mta:Moth_1763 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; SPTR: A1HU83 Dihydrolipoyl dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase.
 
  
 0.917
Deba_2985
Protein of unknown function DUF224 cysteine-rich region domain protein; COGs: COG0247 Fe-S oxidoreductase; InterProIPR001450:IPR004017:IPR012285:IPR017896:IPR 009051:IPR017900; KEGG: mac:MA0688 heterodisulfide reductase, subunit D; PFAM: protein of unknown function DUF224 cysteine-rich region domain protein; 4Fe-4S ferredoxin iron-sulfur binding domain protein; SPTR: Q8TSV7 CoB--CoM heterodisulfide reductase 2 iron-sulfur subunit D; PFAM: Cysteine-rich domain.
 
   
 0.829
Deba_3040
COGs: COG0509 Glycine cleavage system H protein (lipoate-binding); InterPro IPR011053:IPR002930:IPR003016; KEGG: mta:Moth_0438 glycine cleavage system H protein; PFAM: glycine cleavage H-protein; SPTR: Q2RLC0 Glycine cleavage system H protein; PFAM: Glycine cleavage H-protein; TIGRFAM: glycine cleavage system H protein.
 
 
 0.819
Deba_2983
Hypothetical protein; InterPro IPR011031; KEGG: sat:SYN_02638 iron-sulphur-binding reductase; SPTR: C8QXC7 Cytochrome C family protein; TIGRFAM: doubled CXXCH domain.
 
     0.810
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 
 0.803
Deba_2979
Transketolase domain protein; COGs: COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit; InterProIPR005475:IPR005476:IPR015941:IPR009014:IPR 013838; KEGG: sso:SSO1526 pyruvate dehydrogenase beta subunit (lipoamide); PFAM: Transketolase domain protein; Transketolase central region; SPTR: B7S015 Transketolase, C-terminal domain protein; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.
 
  
 0.790
Your Current Organism:
Desulfarculus baarsii
NCBI taxonomy Id: 644282
Other names: D. baarsii DSM 2075, Desulfarculus baarsii 2st 14, Desulfarculus baarsii DSM 2075, Desulfarculus baarsii str. DSM 2075, Desulfarculus baarsii strain DSM 2075
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