STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Deba_3171UBA/THIF-type NAD/FAD binding protein; COGs: COG1179 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 1; InterPro IPR009036:IPR000594:IPR016040; KEGG: reh:H16_A1870 ThiF/MoeB/HesA family protein; PFAM: UBA/THIF-type NAD/FAD binding protein; SPTR: A1HS23 UBA/THIF-type NAD/FAD binding protein; PFAM: ThiF family. (270 aa)    
Predicted Functional Partners:
iscS
Cysteine desulfurase NifS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
   
 0.888
Deba_3170
COGs: COG4012 conserved hypothetical protein; InterPro IPR014846; KEGG: mta:Moth_0877 pyruvate formate-lyase activating enzyme; PFAM: Domain of unkown function DUF1786 putative pyruvate format-lyase activating enzyme; SPTR: C0GKM6 Protein of unkown function DUF1786; putative pyruvate format-lyase activating enzyme; PFAM: Putative pyruvate format-lyase activating enzyme (DUF1786).
       0.773
Deba_3172
DNA repair protein RecN; May be involved in recombinational repair of damaged DNA.
       0.773
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
  
 0.759
Deba_1137
COGs: COG0492 Thioredoxin reductase; InterPro IPR000103:IPR013027:IPR005982; KEGG: pth:PTH_1417 thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: A5D2B9 Thioredoxin reductase; TIGRFAM: thioredoxin reductase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: thioredoxin-disulfide reductase.
  
  
 0.758
Deba_0205
Phosphomethylpyrimidine kinase; COGs: COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; InterPro IPR013749:IPR004399; KEGG: pla:Plav_2132 phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; SPTR: A7HV13 Phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase.
  
  
 0.735
Deba_1999
Protein of unknown function DUF181; COGs: COG1944 conserved hypothetical protein; InterProIPR019734:IPR003776:IPR001440:IPR013105:IPR 013026:IPR011990; KEGG: dol:Dole_1241 hypothetical protein; PFAM: protein of unknown function DUF181; TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; SPTR: A8ZY40 Putative uncharacterized protein; PFAM: YcaO-like family; Tetratricopeptide repeat; TIGRFAM: uncharacterized domain; bacteriocin biosynthesis docking scaffold, SagD family.
  
 0.707
thiC
Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
  
  
 0.699
Deba_2032
COGs: COG0422 Thiamine biosynthesis protein ThiC; InterPro IPR002817; KEGG: geo:Geob_0543 thiamine biosynthesis protein ThiC; PFAM: thiamine biosynthesis protein ThiC; SPTR: B9LZU6 Thiamine biosynthesis protein ThiC; TIGRFAM: thiamine biosynthesis protein ThiC; PFAM: ThiC family; TIGRFAM: thiamine biosynthesis protein ThiC.
  
  
 0.699
Deba_3097
Tetratricopeptide TPR_2 repeat protein; InterProIPR001440:IPR013105:IPR019734:IPR013026:IPR 011990; KEGG: dat:HRM2_20780 tetratricopeptide (TPR) domain protein; PFAM: Tetratricopeptide TPR_2 repeat protein; TPR repeat-containing protein; SPTR: C0QDB3 Tetratricopeptide (TPR) domain protein; PFAM: ChAPs (Chs5p-Arf1p-binding proteins); TIGRFAM: putative PEP-CTERM system TPR-repeat lipoprotein.
  
 0.699
Your Current Organism:
Desulfarculus baarsii
NCBI taxonomy Id: 644282
Other names: D. baarsii DSM 2075, Desulfarculus baarsii 2st 14, Desulfarculus baarsii DSM 2075, Desulfarculus baarsii str. DSM 2075, Desulfarculus baarsii strain DSM 2075
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