STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ruvCCrossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (168 aa)    
Predicted Functional Partners:
ruvA
Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
 
 
 0.995
ruvB
Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
 
 
 0.966
Deba_3239
Protein of unknown function DUF28; COGs: COG0217 conserved hypothetical protein; InterPro IPR002876:IPR017856; KEGG: dat:HRM2_04000 hypothetical protein; PFAM: protein of unknown function DUF28; SPTR: C0QGP3 UPF0082 protein HRM2_04000; PFAM: Domain of unknown function DUF28; TIGRFAM: conserved hypothetical protein TIGR01033.
 
  
 0.859
rlmE
Ribosomal RNA methyltransferase RrmJ/FtsJ; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
       0.795
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
   
 0.708
Deba_3241
Thioesterase superfamily protein; COGs: COG2050 Uncharacterized protein possibly involved in aromatic compounds catabolism; InterPro IPR006683; KEGG: pfl:PFL_2301 thioesterase family protein; PFAM: thioesterase superfamily protein; SPTR: Q4KEC5 Thioesterase family protein; PFAM: Thioesterase superfamily; TIGRFAM: uncharacterized domain 1.
       0.590
Deba_3242
NAD-dependent epimerase/dehydratase; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR016040:IPR001509; KEGG: dal:Dalk_1637 NAD-dependent epimerase/dehydratase; PFAM: NAD-dependent epimerase/dehydratase; SPTR: B8FAN9 NAD-dependent epimerase/dehydratase; PFAM: NAD dependent epimerase/dehydratase family.
       0.590
Deba_3024
DNA internalization-related competence protein ComEC/Rec2; COGs: COG2333 hydrolase (metallo-beta-lactamase superfamily); InterPro IPR004477:IPR004797; KEGG: dal:Dalk_2782 DNA internalization-related competence protein ComEC/Rec2; PFAM: ComEC/Rec2-related protein; SPTR: B8FKV2 DNA internalization-related competence protein ComEC/Rec2; TIGRFAM: DNA internalization-related competence protein ComEC/Rec2; ComEC/Rec2-related protein; PFAM: Competence protein; Metallo-beta-lactamase superfamily; TIGRFAM: ComEC/Rec2-related protein; DNA internalization-related competence protein ComEC/Rec2.
     
 0.566
Deba_1509
single-stranded-DNA-specific exonuclease RecJ; COGs: COG0608 Single-stranded DNA-specific exonuclease; InterPro IPR001667:IPR003156:IPR004610; KEGG: ade:Adeh_2536 single-stranded-DNA-specific exonuclease RecJ; PFAM: phosphoesterase RecJ domain protein; phosphoesterase DHHA1; SPTR: Q2IKX4 Single-stranded-DNA-specific exonuclease RecJ; TIGRFAM: single-stranded-DNA-specific exonuclease RecJ; PFAM: DHH family; DHHA1 domain; TIGRFAM: single-stranded-DNA-specific exonuclease RecJ.
 
 
 
 0.539
Deba_2484
Mg chelatase, subunit ChlI; COGs: COG0606 ATPase with chaperone activity; InterProIPR004482:IPR003593:IPR020568:IPR000523:IPR 001208; KEGG: dal:Dalk_5279 Mg chelatase, subunit ChlI; PFAM: magnesium chelatase ChlI subunit; SMART: AAA ATPase; SPTR: C6MTP3 Mg chelatase, subunit ChlI; TIGRFAM: Mg chelatase, subunit ChlI; PFAM: Magnesium chelatase, subunit ChlI; Lon protease (S16) C-terminal proteolytic domain; TIGRFAM: Mg chelatase-related protein.
 
   
 0.529
Your Current Organism:
Desulfarculus baarsii
NCBI taxonomy Id: 644282
Other names: D. baarsii DSM 2075, Desulfarculus baarsii 2st 14, Desulfarculus baarsii DSM 2075, Desulfarculus baarsii str. DSM 2075, Desulfarculus baarsii strain DSM 2075
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