STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADL43579.1SMART: DNA gyrase/topoisomerase IV subunit A; Hedgehog/intein hint domain protein; TIGRFAM: DNA gyrase, A subunit; KEGG: mkm:Mkms_0015 DNA gyrase subunit A; PFAM: DNA gyrase/topoisomerase IV subunit A; DNA gyrase repeat beta-propeller. (1259 aa)    
Predicted Functional Partners:
gyrB
DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
 
 0.996
ADL45616.1
PFAM: DNA gyrase subunit B domain protein; DNA topoisomerase type IIA subunit B region 2 domain protein; ATP-binding region ATPase domain protein; TOPRIM domain-containing protein; KEGG: saq:Sare_1674 DNA gyrase subunit B; SMART: DNA topoisomerase II; ATP-binding region ATPase domain protein.
 
 0.981
ADL48501.1
Hypothetical protein; KEGG: DNA gyrase, B subunit.
  
 
 0.927
ADL43580.1
PFAM: Protein of unknown function DUF3566. transmembrane; KEGG: stp:Strop_0010 hypothetical protein.
  
  
 0.902
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
   
 0.782
ADL44953.1
TIGRFAM: signal peptidase I; KEGG: saq:Sare_1199 signal peptidase I; PFAM: Peptidase S26, conserved region; Peptidase S24/S26A/S26B, conserved region; Belongs to the peptidase S26 family.
  
  
 0.779
ADL47419.1
Beta-ketoacyl synthase; KEGG: cai:Caci_2598 KR domain protein; PFAM: Beta-ketoacyl synthase; KR domain protein; Enoyl-CoA hydratase/isomerase; phosphopantetheine-binding; Methyltransferase type 12; aromatic amino acid beta-eliminating lyase/threonine aldolase; alpha/beta hydrolase fold; SMART: Polyketide synthase, beta-ketoacyl synthase region; Polyketide synthase, phosphopantetheine-binding; Polyketide synthase/Fatty acid synthase, KR.
  
  
 0.759
rpoB
DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
  
 0.740
dnaJ-2
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
  
  
 0.711
uvrB
Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
 
  
 0.707
Your Current Organism:
Micromonospora aurantiaca
NCBI taxonomy Id: 644283
Other names: M. aurantiaca ATCC 27029, Micromonospora aurantiaca ATCC 27029, Micromonospora aurantiaca str. ATCC 27029, Micromonospora aurantiaca strain ATCC 27029
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