STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADL44518.1TIGRFAM: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit; 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofG subunit; PFAM: Radical SAM domain protein; KEGG: saq:Sare_0888 FO synthase; SMART: Elongator protein 3/MiaB/NifB. (841 aa)    
Predicted Functional Partners:
ADL44516.1
LPPG domain protein containing protein; KEGG: saq:Sare_0886 LPPG:FO 2-phospho-L-lactate transferase; TIGRFAM: LPPG domain protein containing protein; PFAM: protein of unknown function UPF0052 and CofD.
 
  
 0.989
ADL47214.1
TIGRFAM: PAS sensor protein; PFAM: Stage II sporulation protein E; response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; KEGG: kfl:Kfla_4457 multi-sensor signal transduction histidine kinase; SMART: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS domain containing protein; protein phosphatase 2C domain protein.
  
 
 0.869
ADL45011.1
Stage II sporulation protein E; KEGG: sro:Sros_7544 signal transduction histidine kinase-like protein; PFAM: Stage II sporulation protein E; response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; SMART: protein phosphatase 2C domain protein; response regulator receiver; histidine kinase A domain protein; ATP-binding region ATPase domain protein; GAF domain protein.
   
  
 0.851
thiG
Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
  
 
 0.836
ADL44515.1
KEGG: stp:Strop_0943 F420-dependent oxidoreductase, putative; TIGRFAM: F420-dependent oxidoreductase; PFAM: protein of unknown function DUF129.
 
   
 0.834
ADL45751.1
Stage II sporulation protein E; KEGG: sma:SAV_7504 magnesium or manganese-dependent protein phosphatase; PFAM: Stage II sporulation protein E; PAS fold-4 domain protein; ATP-binding region ATPase domain protein; SMART: protein phosphatase 2C domain protein; ATP-binding region ATPase domain protein; PAS domain containing protein; GAF domain protein.
   
    0.812
thiC
Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
  
 0.802
fbiD
2-phospho-L-lactate guanylyltransferase CofC; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
 
   
 0.753
ADL45694.1
KEGG: sco:SCO6786 oxidoreductase; TIGRFAM: putative F420-dependent oxidoreductase; PFAM: Luciferase-like, subgroup.
 
   
 0.693
ADL48992.1
KEGG: stp:Strop_3887 thiamine biosynthesis protein ThiS; TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein.
  
  
 0.688
Your Current Organism:
Micromonospora aurantiaca
NCBI taxonomy Id: 644283
Other names: M. aurantiaca ATCC 27029, Micromonospora aurantiaca ATCC 27029, Micromonospora aurantiaca str. ATCC 27029, Micromonospora aurantiaca strain ATCC 27029
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.