def-2 protein (Micromonospora aurantiaca) - STRING interaction network

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def-2

Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (167 aa)

Predicted Functional Partners:

rplV

0.732

rplI

0.695

rplQ

0.689

rplT

0.673

rplU

0.672

rplR

0.654

tig

0.642

rplK

0.632

rpsT

0.623

rpsJ

0.623

Your Current Organism:

Micromonospora aurantiaca

NCBI taxonomy Id: 644283
Other names: M. aurantiaca ATCC 27029, Micromonospora aurantiaca ATCC 27029, Micromonospora aurantiaca str. ATCC 27029, Micromonospora aurantiaca strain ATCC 27029

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
def-2	rplI	Micau_3205	Micau_6264	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	Ribosomal protein L9; Binds to the 23S rRNA.	0.695
def-2	rplK	Micau_3205	Micau_5542	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.	0.632
def-2	rplQ	Micau_3205	Micau_5496	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	KEGG: stp:Strop_3894 ribosomal protein L17; TIGRFAM: ribosomal protein L17; PFAM: ribosomal protein L17.	0.689
def-2	rplR	Micau_3205	Micau_5511	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	Ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.	0.654
def-2	rplT	Micau_3205	Micau_2367	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	Ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.	0.673
def-2	rplU	Micau_3205	Micau_4888	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	Ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.	0.672
def-2	rplV	Micau_3205	Micau_5522	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	Ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.	0.732
def-2	rpsJ	Micau_3205	Micau_5528	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	Ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family.	0.623
def-2	rpsT	Micau_3205	Micau_4865	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	Ribosomal protein S20; Binds directly to 16S ribosomal RNA.	0.623
def-2	tig	Micau_3205	Micau_4913	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	Trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily.	0.642
rplI	def-2	Micau_6264	Micau_3205	Ribosomal protein L9; Binds to the 23S rRNA.	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	0.695
rplI	rplK	Micau_6264	Micau_5542	Ribosomal protein L9; Binds to the 23S rRNA.	Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.	0.993
rplI	rplQ	Micau_6264	Micau_5496	Ribosomal protein L9; Binds to the 23S rRNA.	KEGG: stp:Strop_3894 ribosomal protein L17; TIGRFAM: ribosomal protein L17; PFAM: ribosomal protein L17.	0.994
rplI	rplR	Micau_6264	Micau_5511	Ribosomal protein L9; Binds to the 23S rRNA.	Ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.	0.993
rplI	rplT	Micau_6264	Micau_2367	Ribosomal protein L9; Binds to the 23S rRNA.	Ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.	0.997
rplI	rplU	Micau_6264	Micau_4888	Ribosomal protein L9; Binds to the 23S rRNA.	Ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.	0.994
rplI	rplV	Micau_6264	Micau_5522	Ribosomal protein L9; Binds to the 23S rRNA.	Ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.	0.993
rplI	rpsJ	Micau_6264	Micau_5528	Ribosomal protein L9; Binds to the 23S rRNA.	Ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family.	0.986
rplI	rpsT	Micau_6264	Micau_4865	Ribosomal protein L9; Binds to the 23S rRNA.	Ribosomal protein S20; Binds directly to 16S ribosomal RNA.	0.968
rplI	tig	Micau_6264	Micau_4913	Ribosomal protein L9; Binds to the 23S rRNA.	Trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily.	0.977

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