STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
egtDMethyltransferase; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. (321 aa)    
Predicted Functional Partners:
egtB
Protein of unknown function DUF323; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine; Belongs to the EgtB family.
 
 0.999
egtC
Hypothetical protein; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.
  
 0.995
egtA
Glutamate/cysteine ligase family protein; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine.
 
  
 0.975
ADL44724.1
TIGRFAM: histidine ammonia-lyase; KEGG: stp:Strop_1106 histidine ammonia-lyase; PFAM: phenylalanine/histidine ammonia-lyase.
     
  0.900
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
     
  0.900
ADL49630.1
PFAM: Pyridoxal-dependent decarboxylase; KEGG: mlo:mlr6209 histidine decarboxylase.
     
  0.900
ADL48599.1
Protein of unknown function DUF323; KEGG: sro:Sros_3062 non-specific serine/threonine protein kinase; manually curated; PFAM: protein of unknown function DUF323.
 
  
 0.750
ADL44566.1
PFAM: protein of unknown function DUF58; KEGG: sna:Snas_1844 hypothetical protein.
      
 0.644
purD
Phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; manually curated; KEGG: saq:Sare_0140 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine/glycine ligase; Belongs to the GARS family.
      
 0.637
ADL44242.1
KEGG: saq:Sare_0669 citryl-CoA lyase; PFAM: HpcH/HpaI aldolase; Belongs to the HpcH/HpaI aldolase family.
      
 0.617
Your Current Organism:
Micromonospora aurantiaca
NCBI taxonomy Id: 644283
Other names: M. aurantiaca ATCC 27029, Micromonospora aurantiaca ATCC 27029, Micromonospora aurantiaca str. ATCC 27029, Micromonospora aurantiaca strain ATCC 27029
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.