STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (343 aa)    
Predicted Functional Partners:
ADL45183.1
Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
 
 
 0.995
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
  
 0.981
ADL45184.1
PFAM: Chlorite dismutase; KEGG: stp:Strop_1534 chlorite dismutase.
  
 0.967
ADL44607.1
KEGG: kra:Krad_1097 magnesium chelatase, ChlI subunit.
 
 
 0.936
hmuV
Heme oxygenase-like; Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system.
    
 0.921
ctaB
Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
   
 
 0.921
ADL45390.1
PFAM: Radical SAM domain protein; KEGG: dal:Dalk_5124 radical SAM domain protein.
  
 
 0.918
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
  
 0.838
ADL47751.1
TIGRFAM: HAD-superfamily hydrolase, subfamily IIA; KEGG: saq:Sare_3248 HAD family hydrolase; Belongs to the HAD-like hydrolase superfamily.
       0.827
ADL47753.1
PFAM: short-chain dehydrogenase/reductase SDR; KEGG: saq:Sare_3250 enoyl-(acyl carrier protein) reductase.
 
   
 0.774
Your Current Organism:
Micromonospora aurantiaca
NCBI taxonomy Id: 644283
Other names: M. aurantiaca ATCC 27029, Micromonospora aurantiaca ATCC 27029, Micromonospora aurantiaca str. ATCC 27029, Micromonospora aurantiaca strain ATCC 27029
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