STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADL47945.1PFAM: regulatory protein TetR; KEGG: saq:Sare_3404 TetR family transcriptional regulator. (198 aa)    
Predicted Functional Partners:
ADL47944.1
KEGG: saq:Sare_3403 multidrug ABC transporter inner membrane protein; TIGRFAM: ABC drug efflux pump, inner membrane subunit, DrrB family; PFAM: ABC-2 type transporter.
 
     0.902
ADL47943.1
KEGG: saq:Sare_3402 ABC transporter related; PFAM: ABC transporter related; SMART: AAA ATPase.
 
     0.886
ADL47942.1
Regulatory protein MerR; KEGG: avn:Avin_02350 transcriptional regulator, MerR family; PFAM: regulatory protein MerR; Transcription regulator MerR DNA binding; SMART: regulatory protein MerR.
       0.541
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
     
 0.425
hisI
Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
       0.422
ADL46667.1
PFAM: regulatory protein TetR; KEGG: chl:Chy400_2245 transcriptional regulator, TetR family.
  
     0.419
ADL47939.1
PFAM: Trp biosynthesis associated, transmembrane protein, Oprn/Chp; KEGG: saq:Sare_3399 hypothetical protein.
       0.411
Your Current Organism:
Micromonospora aurantiaca
NCBI taxonomy Id: 644283
Other names: M. aurantiaca ATCC 27029, Micromonospora aurantiaca ATCC 27029, Micromonospora aurantiaca str. ATCC 27029, Micromonospora aurantiaca strain ATCC 27029
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