STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Arch_0004Protein of unknown function DUF721; COGs: COG5512 Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives; InterPro IPR007922; KEGG: bcv:Bcav_0005 protein of unknown function DUF721; PFAM: protein of unknown function DUF721; SPTR: D0WL05 Protein in RecF-GyrB intergenic region; PFAM: Protein of unknown function (DUF721). (194 aa)    
Predicted Functional Partners:
recF
DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family.
 
  
 0.918
Arch_0002
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
     
 0.901
Arch_1728
Metallophosphoesterase; COGs: COG1408 phosphohydrolase; InterPro IPR004843; KEGG: bcv:Bcav_0603 metallophosphoesterase; PFAM: metallophosphoesterase; SPTR: D0WK61 Ser/Thr protein phosphatase family protein; PFAM: Calcineurin-like phosphoesterase.
  
     0.770
Arch_0799
KEGG: bcv:Bcav_1965 hypothetical protein; SPTR: D0WQH2 Putative uncharacterized protein; PFAM: Protein of unknown function (DUF3000).
  
     0.736
Arch_0007
KEGG: kra:Krad_0008 hypothetical protein; SPTR: D0WL02 Putative integral membrane protein; PFAM: Transmembrane domain of unknown function (DUF3566).
 
     0.731
Arch_1515
Septum formation initiator; InterPro IPR007060; KEGG: bcv:Bcav_1019 septum formation initiator; PFAM: Septum formation initiator; SPTR: D0WQ09 Putative membrane protein; PFAM: Septum formation initiator.
  
     0.729
Arch_1231
UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR014016:IPR014017:IPR000212; KEGG: jde:Jden_0711 UvrD/REP helicase; PFAM: UvrD/REP helicase; SPTR: D0WNM4 Helicase, UvrD/Rep family; PFAM: Domain of unknown function DUF83; UvrD/REP helicase.
  
   
 0.692
Arch_0204
KEGG: bcv:Bcav_3525 hypothetical protein; SPTR: C5C2S3 Putative uncharacterized protein.
  
     0.655
Arch_1514
Protein of unknown function DUF501; COGs: COG1507 conserved hypothetical protein; InterPro IPR007511; KEGG: jde:Jden_1921 protein of unknown function DUF501; PFAM: protein of unknown function DUF501; SPTR: D0WQ08 Septum formation initiator family protein; PFAM: Protein of unknown function (DUF501).
  
     0.651
gyrB
DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.650
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.