STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Arch_0007KEGG: kra:Krad_0008 hypothetical protein; SPTR: D0WL02 Putative integral membrane protein; PFAM: Transmembrane domain of unknown function (DUF3566). (144 aa)    
Predicted Functional Partners:
Arch_0006
COGs: COG0188 Type IIA topoisomerase (DNA gyrase/topo II topoisomerase IV) A subunit; InterProIPR002205:IPR006691:IPR013758:IPR013757:IPR 005743:IPR013760; KEGG: bcv:Bcav_0007 DNA gyrase, A subunit; PFAM: DNA gyrase/topoisomerase IV subunit A; DNA gyrase repeat beta-propeller; PRIAM: DNA topoisomerase (ATP-hydrolyzing); SMART: DNA gyrase/topoisomerase IV subunit A; SPTR: D0WL03 DNA gyrase, A subunit; TIGRFAM: DNA gyrase, A subunit; PFAM: DNA gyrase/topoisomerase IV, subunit A; DNA gyrase C-terminal domain, beta-propeller; TIGRFAM: DNA gyrase, A subunit.
  
  
 0.880
gyrB
DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
     
 0.733
Arch_0004
Protein of unknown function DUF721; COGs: COG5512 Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives; InterPro IPR007922; KEGG: bcv:Bcav_0005 protein of unknown function DUF721; PFAM: protein of unknown function DUF721; SPTR: D0WL05 Protein in RecF-GyrB intergenic region; PFAM: Protein of unknown function (DUF721).
 
     0.731
Arch_0680
Protein of unknown function YGGT; InterPro IPR003425; KEGG: fra:Francci3_1422 hypothetical protein; PFAM: protein of unknown function YGGT; SPTR: C2BWZ3 Transmembrane protein; PFAM: YGGT family.
  
     0.668
rbpA
Hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.
  
     0.665
Arch_1621
KEGG: kra:Krad_3581 hypothetical protein; SPTR: D0WJT3 Putative uncharacterized protein; PFAM: Protein of unknown function (DUF3027).
  
     0.665
Arch_1118
KEGG: bcv:Bcav_2744 hypothetical protein; SPTR: D0WNJ1 Putative uncharacterized protein; PFAM: Protein of unknown function (DUF3039).
  
     0.662
Arch_0376
COGs: COG3118 Thioredoxin domain-containing protein; InterPro IPR012335:IPR012336; KEGG: bcv:Bcav_1333 thioredoxin domain protein; SPTR: D0WRU8 Thioredoxin-related protein; PFAM: Thioredoxin.
 
     0.655
Arch_0002
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
 
   
 0.649
Arch_0719
KEGG: bcv:Bcav_1811 hypothetical protein; SPTR: C0W3W7 Putative uncharacterized protein; PFAM: Protein of unknown function (DUF3052).
  
     0.632
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.