STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
Arch_0026Exo-alpha-sialidase; COGs: COG4409 Neuraminidase (sialidase); InterPro IPR011040; KEGG: pac:PPA1560 sialidase precursor; PRIAM: Exo-alpha-sialidase; SPTR: Q44562 Sialidase; PFAM: BNR/Asp-box repeat. (885 aa)    
Predicted Functional Partners:
Arch_0158
Glycoside hydrolase, family 20, catalytic core; COGs: COG3525 N-acetyl-beta-hexosaminidase; InterPro IPR015883:IPR013781:IPR017853:IPR001540; KEGG: sco:SCO4860 secreted hydrolase; PFAM: Glycoside hydrolase, family 20, catalytic core; SPTR: C8P1S6 Lacto-N-biosidase; PFAM: Glycosyl hydrolase family 20, catalytic domain.
 
 0.936
Arch_1292
LPXTG-motif cell wall anchor domain protein; COGs: COG3250 Beta-galactosidase/beta-glucuronidase; InterProIPR000421:IPR006104:IPR006102:IPR006103:IPR 011081:IPR011080:IPR013781:IPR019931:IPR017853:IPR008979:I PR006101; KEGG: apv:Apar_0102 glycoside hydrolase family 2 sugar binding; PFAM: glycoside hydrolase family 2 sugar binding; glycoside hydrolase family 2 immunoglobulin domain protein beta-sandwich; glycoside hydrolase family 2 TIM barrel; Ig domain protein; coagulation factor 5/8 type domain protein; SPTR: A4K5H9 Beta-galactosidase BbgIII; TIGRFAM: LPXTG-motif cell wall anchor dom [...]
 
  
 0.926
Arch_1299
LPXTG-motif cell wall anchor domain protein; COGs: COG4409 Neuraminidase (sialidase); InterPro IPR002860:IPR019931:IPR011040; KEGG: bln:Blon_2348 exo-alpha-sialidase; PFAM: glycosyl hydrolase BNR repeat-containing protein; SPTR: B7GNQ0 Exo-alpha-sialidase; TIGRFAM: LPXTG-motif cell wall anchor domain protein; PFAM: BNR/Asp-box repeat.
  
  
 
0.926
Arch_0722
Glycoside hydrolase, family 20, catalytic core; COGs: COG3525 N-acetyl-beta-hexosaminidase; InterProIPR001540:IPR017853:IPR008979:IPR000421:IPR 013781:IPR015883; KEGG: sgr:SGR_2685 putative beta-N-acetylglucosaminidase; PFAM: Glycoside hydrolase, family 20, catalytic core; coagulation factor 5/8 type domain protein; SPTR: A8REL0 Putative uncharacterized protein; PFAM: F5/8 type C domain; Glycosyl hydrolase family 20, catalytic domain; TIGRFAM: LPXTG-motif cell wall anchor domain.
  
 0.925
Arch_0959
COGs: COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; InterPro IPR020625:IPR013785:IPR002220; KEGG: ckp:ckrop_1871 dihydrodipicolinate synthase; PFAM: dihydrodipicolinate synthetase; SPTR: C0W1Z6 Possible dihydrodipicolinate synthase; PFAM: Dihydrodipicolinate synthetase family; Belongs to the DapA family.
 
   
 0.681
Arch_0393
UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR002121:IPR014016:IPR014017:IPR000212; KEGG: bcv:Bcav_2897 UvrD/REP helicase; PFAM: UvrD/REP helicase; HRDC domain protein; SMART: HRDC domain protein; SPTR: D0WRX3 ATP-dependent DNA helicase II; PFAM: HRDC domain; UvrD/REP helicase.
  
 
 0.668
Arch_0961
Oligopeptide/dipeptide ABC transporter, ATPase subunit; COGs: COG0444 ABC-type dipeptide/oligopeptide/nickel transport system ATPase component; InterProIPR010066:IPR003439:IPR000515:IPR017871:IPR 003593:IPR013563; KEGG: ele:Elen_2148 oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter related; binding-protein-dependent transport systems inner membrane component; Oligopeptide/dipeptide ABC transporter domain protein; SMART: AAA ATPase; SPTR: A7BBZ1 Putative uncharacterized protein; TIGRFAM: oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC trans [...]
 
    0.609
gyrB
DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.537
Arch_0763
COGs: COG0187 Type IIA topoisomerase (DNA gyrase/topo II topoisomerase IV) B subunit; InterProIPR001241:IPR000565:IPR013760:IPR003594:IPR 020568:IPR018522:IPR013759:IPR013506:IPR006171:IPR002288; KEGG: bcv:Bcav_1922 DNA topoisomerase (ATP-hydrolyzing); PFAM: DNA topoisomerase type IIA subunit B region 2 domain protein; ATP-binding region ATPase domain protein; TOPRIM domain protein; DNA gyrase subunit B domain protein; PRIAM: DNA topoisomerase (ATP-hydrolyzing); SMART: DNA topoisomerase II; ATP-binding region ATPase domain protein; SPTR: D0WQJ3 Putative DNA gyrase subunit B; PFAM: Topr [...]
   
 
 0.537
Arch_0497
Glycoside hydrolase family 29 (alpha-L-fucosidase); COGs: COG3669 Alpha-L-fucosidase; InterPro IPR013781:IPR000933:IPR017853:IPR016286; KEGG: pac:PPA0607 glycosyl hydrolase, putative alpha-L-fucosidase; PFAM: glycoside hydrolase family 29 (alpha-L-fucosidase); SMART: glycoside hydrolase family 29 (alpha-L-fucosidase); SPTR: Q6AA53 Glycosyl hydrolase, putative alpha-L-fucosidase; PFAM: Alpha-L-fucosidase.
  
   
 0.511
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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