STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Arch_0048Thiamine pyrophosphate protein central region; COGs: COG3962 Acetolactate synthase; InterPro IPR012001:IPR012000:IPR011766; KEGG: pac:PPA0459 thiamine pyrophosphate-requiring enzyme, putative acetolactate synthase; PFAM: thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein domain protein TPP-binding; SPTR: D0YPL2 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate e [...] (627 aa)    
Predicted Functional Partners:
Arch_0047
Myo-inositol catabolism IolB domain protein; COGs: COG3718 Uncharacterized protein involved in inositol metabolism; InterPro IPR010669:IPR011051; KEGG: rop:ROP_10680 5-deoxy-glucuronate isomerase; PFAM: Myo-inositol catabolism IolB domain protein; SPTR: D0YPL3 5-deoxy-glucuronate isomerase; PFAM: KduI/IolB family.
 
 
 0.999
Arch_0041
Myo-inosose-2 dehydratase; COGs: COG1082 Sugar phosphate isomerase/epimerase; InterPro IPR012307:IPR013022; KEGG: pac:PPA0468 putative myo-inositol catabolism protein; PFAM: Xylose isomerase domain protein TIM barrel; PRIAM: Myo-inosose-2 dehydratase; SPTR: D0YPM5 Sugar phosphate isomerase/epimerase IolE; PFAM: Xylose isomerase-like TIM barrel.
 
 
 0.997
Arch_0045
PfkB domain protein; COGs: COG0524 Sugar kinase ribokinase family; InterPro IPR011611:IPR002139; KEGG: rer:RER_20210 5-dehydro-2-deoxygluconokinase; PFAM: PfkB domain protein; SPTR: C0W6K8 Possible 5-dehydro-2-deoxygluconokinase; PFAM: pfkB family carbohydrate kinase.
 
  
 0.973
Arch_0042
Oxidoreductase domain protein; COGs: COG0673 dehydrogenase and related protein; InterPro IPR000683:IPR004104:IPR016040; KEGG: pac:PPA0469 putative myo-inositol 2-dehydrogenase; PFAM: oxidoreductase domain protein; Oxidoreductase domain; SPTR: C0W6K5 Inositol 2-dehydrogenase; PFAM: Oxidoreductase family, NAD-binding Rossmann fold; Oxidoreductase family, C-terminal alpha/beta domain.
 
  
 0.959
Arch_0046
KEGG: sro:Sros_5538 hypothetical protein; SPTR: D0YPL4 Deoxyribose-phosphate aldolase superfamily protein.
 
  
 0.945
Arch_0049
COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590:IPR016162:IPR010061:IPR016161; KEGG: pac:PPA0461 methylmalonic acid semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: C0W6L2 Methylmalonate-semialdehyde dehydrogenase (Acylating); TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde dehydrogenase family; TIGRFAM: methylmalonic acid semialdehyde dehydrogenase.
  
 0.857
Arch_0441
Hypothetical protein; KEGG: ach:Achl_0779 oxidoreductase domain protein; SPTR: B8HC64 Oxidoreductase domain protein.
  
  
 0.752
Arch_0044
Transcriptional regulator, GntR family; COGs: COG2188 Transcriptional regulators; InterPro IPR000524:IPR011663:IPR011991; KEGG: msm:MSMEG_4659 GntR-family protein transcriptional regulator; PFAM: UbiC transcription regulator-associated domain protein; regulatory protein GntR HTH; SMART: regulatory protein GntR HTH; SPTR: C2KTD8 Transcriptional regulator; PFAM: Bacterial regulatory proteins, gntR family; UTRA domain.
 
  
 0.675
Arch_0043
Transaldolase; COGs: COG0176 Transaldolase; InterPro IPR001585:IPR013785; KEGG: pac:PPA0454 transaldolase; PFAM: Transaldolase; SPTR: Q6AAL0 Transaldolase; PFAM: Transaldolase.
 
  
 0.630
Arch_0036
PfkB domain protein; COGs: COG0524 Sugar kinase ribokinase family; InterPro IPR011611:IPR002173; KEGG: bcv:Bcav_1099 fructokinase; PFAM: PfkB domain protein; SPTR: C1RNV6 Sugar kinase, ribokinase; PFAM: pfkB family carbohydrate kinase.
  
  
 0.484
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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