STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Arch_0184Exodeoxyribonuclease III Xth; COGs: COG0708 Exonuclease III; InterPro IPR005135:IPR004808; KEGG: jde:Jden_2428 exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase; SPTR: D0WLN3 Exodeoxyribonuclease III; TIGRFAM: exodeoxyribonuclease III Xth; PFAM: Endonuclease/Exonuclease/phosphatase family; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III (xth). (269 aa)    
Predicted Functional Partners:
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.946
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
  
 0.934
Arch_1274
Exodeoxyribonuclease III Xth; COGs: COG0708 Exonuclease III; InterPro IPR004808:IPR005135; KEGG: jde:Jden_0698 exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase; SPTR: D0WNQ6 Exodeoxyribonuclease III; TIGRFAM: exodeoxyribonuclease III Xth; PFAM: Endonuclease/Exonuclease/phosphatase family; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III (xth).
 
  
 
0.929
Arch_0002
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.921
Arch_0269
HhH-GPD family protein; COGs: COG1194 A/G-specific DNA glycosylase; InterProIPR003265:IPR003583:IPR003651:IPR011257:IPR 004036; KEGG: bcv:Bcav_3282 HhH-GPD family protein; PFAM: HhH-GPD family protein; iron-sulfur cluster loop; SMART: HhH-GPD family protein; Helix-hairpin-helix DNA-binding class 1; SPTR: D0WM02 A/G-specific adenine glycosylase; PFAM: HhH-GPD superfamily base excision DNA repair protein; Helix-hairpin-helix motif; TIGRFAM: A/G-specific adenine glycosylase.
    
 0.898
ung
uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
   
 0.862
Arch_1702
COGs: COG2812 DNA polymerase III gamma/tau subunits; KEGG: xce:Xcel_0355 DNA polymerase III, delta prime subunit; SPTR: D1BVC3 DNA polymerase III, delta prime subunit; PFAM: ATPase family associated with various cellular activities (AAA); TIGRFAM: DNA polymerase III, delta' subunit.
   
  0.828
Arch_1480
Uracil-DNA glycosylase superfamily; COGs: COG3663 G:T/U mismatch-specific DNA glycosylase; InterPro IPR005122; KEGG: bln:Blon_0119 uracil-DNA glycosylase superfamily; PFAM: Uracil-DNA glycosylase superfamily; SPTR: B7GT25 Uracil-DNA glycosylase superfamily; PFAM: Uracil DNA glycosylase superfamily; TIGRFAM: mismatch-specific thymine-DNA glycosylate (mug).
  
 
 0.804
tadA
CMP/dCMP deaminase zinc-binding protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family.
   
 
 0.765
Arch_0875
Pseudouridine synthase; COGs: COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthase; InterProIPR020103:IPR018496:IPR002942:IPR000748:IPR 006145; KEGG: bcv:Bcav_2153 pseudouridine synthase; PFAM: pseudouridine synthase; RNA-binding S4 domain protein; SMART: RNA-binding S4 domain protein; SPTR: D0WMU3 Ribosomal large subunit pseudouridine synthase B; PFAM: RNA pseudouridylate synthase; S4 domain; TIGRFAM: pseudouridine synthase family; Belongs to the pseudouridine synthase RsuA family.
  
    0.716
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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