STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
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[Homology]
Score
pckGPhosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (616 aa)    
Predicted Functional Partners:
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
    
 0.949
Arch_0899
COGs: COG0469 Pyruvate kinase; InterProIPR015793:IPR015813:IPR015795:IPR011037:IPR 018209:IPR015794:IPR001697; KEGG: bcv:Bcav_2215 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; PRIAM: Pyruvate kinase; SPTR: D0WMQ1 Pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family.
   
 
 0.944
Arch_1433
COGs: COG0372 Citrate synthase; InterProIPR002020:IPR016142:IPR010953:IPR016141:IPR 019810; KEGG: ami:Amir_0528 citrate synthase I; PFAM: Citrate synthase; PRIAM: Citrate (Si)-synthase; SPTR: C0W847 Citrate synthase; TIGRFAM: citrate synthase I; PFAM: Citrate synthase; TIGRFAM: citrate synthase I (hexameric type); Belongs to the citrate synthase family.
   
 
 0.937
Arch_0240
Pyruvate, phosphate dikinase; COGs: COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase; InterProIPR002192:IPR008279:IPR000121:IPR013815:IPR 013816:IPR015813:IPR010121:IPR018274; KEGG: tfu:Tfu_0863 pyruvate phosphate dikinase; PFAM: pyruvate phosphate dikinase PEP/pyruvate-binding; PEP-utilising protein mobile region; PEP-utilizing protein; PRIAM: Pyruvate, phosphate dikinase; SPTR: D0WM96 Pyruvate, phosphate dikinase; TIGRFAM: pyruvate, phosphate dikinase; PFAM: PEP-utilising enzyme, TIM barrel domain; PEP-utilising enzyme, mobile domain; Pyruvate phosphate dikinase, PEP/ [...]
     
 0.930
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
     
 0.918
Arch_0202
COGs: COG0334 Glutamate dehydrogenase/leucine dehydrogenase; InterProIPR006097:IPR006096:IPR016040:IPR014362:IPR 006095; KEGG: jde:Jden_2359 glutamate dehydrogenase (NADP(+)); PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; PRIAM: Glutamate dehydrogenase (NADP(+)); SPTR: C0W243 Glutamate dehydrogenase; PFAM: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.874
Arch_1404
Aminotransferase class I and II; COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterProIPR004839:IPR015421:IPR015424:IPR001176:IPR 004838; KEGG: bcv:Bcav_3164 aminotransferase class I and II; PFAM: aminotransferase class I and II; SPTR: D0WPG0 Aspartate transaminase; PFAM: Aminotransferase class I and II.
  
 
 0.838
Arch_0718
2-oxo-acid dehydrogenase E1 subunit, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
   
 
 0.809
argH
COGs: COG0165 Argininosuccinate lyase; InterProIPR008948:IPR009049:IPR020557:IPR000362:IPR 003031; KEGG: drm:Dred_0278 argininosuccinate lyase; PFAM: fumarate lyase; SPTR: B0MQ53 Putative uncharacterized protein; TIGRFAM: argininosuccinate lyase; PFAM: Lyase; TIGRFAM: argininosuccinate lyase.
    
  0.801
Arch_0428
COGs: COG1027 Aspartate ammonia-lyase; InterProIPR020557:IPR000362:IPR003031:IPR018951:IPR 004708:IPR008948; KEGG: hsm:HSM_0765 aspartate ammonia-lyase; PFAM: fumarate lyase; Fumarase C-like; SPTR: B0USK4 Aspartate ammonia-lyase; TIGRFAM: aspartate ammonia-lyase; PFAM: Lyase; Fumarase C C-terminus; TIGRFAM: aspartate ammonia-lyase.
     
  0.800
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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