STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Arch_0248D-alanyl-D-alaninecarboxypeptidase/ D-alanyl-D-alanine-endopeptidase; COGs: COG2027 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4); InterPro IPR000667:IPR012338; KEGG: xce:Xcel_2996 D-alanyl-D-alaninecarboxypeptidase/D-alanyl-D-al anine-endopeptidase; PFAM: peptidase S13 D-Ala-D-Ala carboxypeptidase C; SPTR: D0WMC5 D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase; TIGRFAM: D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase; PFAM: D-Ala-D-Ala carboxypeptidase 3 (S13) family; TIGRFAM: D-alanyl-D-alanine carboxypeptidase, serine-ty [...] (453 aa)    
Predicted Functional Partners:
Arch_0249
COGs: COG5282 conserved hypothetical protein; InterPro IPR018766; KEGG: rsa:RSal33209_3221 putative cytoplasmic protein; PFAM: Protein of unknown function DUF2342; SPTR: D0WMC6 Putative uncharacterized protein; TIGRFAM: conserved hypothetical protein; PFAM: Uncharacterised conserved protein (DUF2342); TIGRFAM: conserved hypothetical protein.
  
  
 0.885
tilS
tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family.
     
 0.825
Arch_0254
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
       0.772
ftsH
ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
       0.676
folE
COGs: COG0302 GTP cyclohydrolase I; InterPro IPR020602:IPR001474:IPR018234; KEGG: art:Arth_0152 GTP cyclohydrolase; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase; PRIAM: GTP cyclohydrolase I; SPTR: C0W610 GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I.
       0.676
Arch_0253
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
       0.667
Arch_0255
KEGG: xce:Xcel_2983 hypothetical protein; SPTR: D1BZ92 Putative uncharacterized protein; PFAM: Protein of unknown function (DUF3180).
       0.661
ppa
Inorganic diphosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
       0.646
Arch_0103
COGs: COG0768 Cell division protein FtsI/penicillin-binding protein 2; InterPro IPR001460:IPR012338; KEGG: jde:Jden_0172 peptidoglycan glycosyltransferase; PFAM: penicillin-binding protein transpeptidase; SPTR: D0WKX2 Penicillin-binding protein 2; PFAM: Penicillin binding protein transpeptidase domain.
      
 0.628
Arch_1803
Peptidoglycan glycosyltransferase; COGs: COG0744 Membrane carboxypeptidase (penicillin-binding protein); InterPro IPR012338:IPR001264:IPR001460; KEGG: bcv:Bcav_4182 glycosyl transferase family 51; PFAM: glycosyl transferase family 51; penicillin-binding protein transpeptidase; PRIAM: Peptidoglycan glycosyltransferase; SPTR: D0WL42 Penicillin-binding protein; manually curated; PFAM: Penicillin binding protein transpeptidase domain; Transglycosylase.
      
 0.624
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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