STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Arch_0256Membrane-flanked domain protein; COGs: COG3402 conserved hypothetical protein; InterPro IPR005182; KEGG: rsa:RSal33209_3209 permease; PFAM: membrane-flanked domain; SPTR: A9WUQ5 Permease; PFAM: Bacterial membrane flanked domain. (162 aa)    
Predicted Functional Partners:
Arch_0257
Membrane-flanked domain protein; COGs: COG3428 membrane protein; InterPro IPR005182; KEGG: bcv:Bcav_0708 membrane-flanked domain protein; PFAM: membrane-flanked domain; SPTR: C5BYL1 Membrane-flanked domain protein; PFAM: Bacterial membrane flanked domain.
 
  
 0.983
Arch_0258
Putative oxidoreductase/dehydrogenase, Rossmann-like domain protein; COGs: COG5495 conserved hypothetical protein; InterPro IPR019665:IPR018931:IPR016040; KEGG: bcv:Bcav_0716 pantoate/beta-alanine ligase; PFAM: Putative oxidoreductase/dehydrogenase, Rossmann-like domain; Domain of unknown function DUF2520; SPTR: C5BYL9 Pantoate/beta-alanine ligase; PFAM: Domain of unknown function (DUF2520); Rossmann-like domain.
       0.822
Arch_0254
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
       0.725
panC
Pantoate/beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
       0.717
panD
Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
       0.717
ftsH
ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
  
    0.651
lysS
COGs: COG1190 Lysyl-tRNA synthetase (class II); InterProIPR004365:IPR004364:IPR012340:IPR006195:IPR 002313:IPR016027:IPR018149; KEGG: jde:Jden_2092 lysyl-tRNA synthetase; PFAM: tRNA synthetase class II (D K and N); nucleic acid binding OB-fold tRNA/helicase-type; PRIAM: Lysine--tRNA ligase; SPTR: D0WLW0 Lysine--tRNA ligase; TIGRFAM: lysyl-tRNA synthetase; PFAM: tRNA synthetases class II (D, K and N); OB-fold nucleic acid binding domain; TIGRFAM: lysyl-tRNA synthetase, eukaryotic and non-spirochete bacterial; Belongs to the class-II aminoacyl-tRNA synthetase family.
       0.599
Arch_0255
KEGG: xce:Xcel_2983 hypothetical protein; SPTR: D1BZ92 Putative uncharacterized protein; PFAM: Protein of unknown function (DUF3180).
       0.591
Arch_0253
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
       0.587
folE
COGs: COG0302 GTP cyclohydrolase I; InterPro IPR020602:IPR001474:IPR018234; KEGG: art:Arth_0152 GTP cyclohydrolase; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase; PRIAM: GTP cyclohydrolase I; SPTR: C0W610 GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I.
       0.580
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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