STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
panCPantoate/beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (275 aa)    
Predicted Functional Partners:
panD
Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
 
 
 0.999
panB
3-methyl-2-oxobutanoatehydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
  
 0.999
Arch_0258
Putative oxidoreductase/dehydrogenase, Rossmann-like domain protein; COGs: COG5495 conserved hypothetical protein; InterPro IPR019665:IPR018931:IPR016040; KEGG: bcv:Bcav_0716 pantoate/beta-alanine ligase; PFAM: Putative oxidoreductase/dehydrogenase, Rossmann-like domain; Domain of unknown function DUF2520; SPTR: C5BYL9 Pantoate/beta-alanine ligase; PFAM: Domain of unknown function (DUF2520); Rossmann-like domain.
   
 0.979
coaA
COGs: COG1072 Panthothenate kinase; InterPro IPR004566; KEGG: xce:Xcel_0666 pantothenate kinase; SPTR: A7B9K0 Putative uncharacterized protein; TIGRFAM: pantothenate kinase; PFAM: Phosphoribulokinase / Uridine kinase family; TIGRFAM: pantothenate kinase, bacterial type.
     
 0.930
cmk
COGs: COG0283 Cytidylate kinase; InterPro IPR003136:IPR000623:IPR011994; KEGG: jde:Jden_1271 cytidylate kinase; PFAM: cytidylate kinase region; shikimate kinase; SPTR: D0WMU4 Prephenate dehydrogenase; TIGRFAM: cytidylate kinase; PFAM: Cytidylate kinase; TIGRFAM: cytidylate kinase.
      0.907
Arch_0855
Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family.
 
 
 0.892
Arch_0254
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
 
   
 0.846
Arch_0256
Membrane-flanked domain protein; COGs: COG3402 conserved hypothetical protein; InterPro IPR005182; KEGG: rsa:RSal33209_3209 permease; PFAM: membrane-flanked domain; SPTR: A9WUQ5 Permease; PFAM: Bacterial membrane flanked domain.
       0.717
Arch_0257
Membrane-flanked domain protein; COGs: COG3428 membrane protein; InterPro IPR005182; KEGG: bcv:Bcav_0708 membrane-flanked domain protein; PFAM: membrane-flanked domain; SPTR: C5BYL1 Membrane-flanked domain protein; PFAM: Bacterial membrane flanked domain.
       0.717
lysS
COGs: COG1190 Lysyl-tRNA synthetase (class II); InterProIPR004365:IPR004364:IPR012340:IPR006195:IPR 002313:IPR016027:IPR018149; KEGG: jde:Jden_2092 lysyl-tRNA synthetase; PFAM: tRNA synthetase class II (D K and N); nucleic acid binding OB-fold tRNA/helicase-type; PRIAM: Lysine--tRNA ligase; SPTR: D0WLW0 Lysine--tRNA ligase; TIGRFAM: lysyl-tRNA synthetase; PFAM: tRNA synthetases class II (D, K and N); OB-fold nucleic acid binding domain; TIGRFAM: lysyl-tRNA synthetase, eukaryotic and non-spirochete bacterial; Belongs to the class-II aminoacyl-tRNA synthetase family.
  
  
 0.701
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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