STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Arch_0269HhH-GPD family protein; COGs: COG1194 A/G-specific DNA glycosylase; InterProIPR003265:IPR003583:IPR003651:IPR011257:IPR 004036; KEGG: bcv:Bcav_3282 HhH-GPD family protein; PFAM: HhH-GPD family protein; iron-sulfur cluster loop; SMART: HhH-GPD family protein; Helix-hairpin-helix DNA-binding class 1; SPTR: D0WM02 A/G-specific adenine glycosylase; PFAM: HhH-GPD superfamily base excision DNA repair protein; Helix-hairpin-helix motif; TIGRFAM: A/G-specific adenine glycosylase. (296 aa)    
Predicted Functional Partners:
Arch_0002
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 
 0.784
Arch_0270
InterPro IPR001647:IPR012287:IPR009057; KEGG: cur:cur_0019 TetR family transcriptional regulator; PFAM: regulatory protein TetR; SPTR: C5VFG3 Transcriptional regulator, TetR family; PFAM: Bacterial regulatory proteins, tetR family.
       0.780
Arch_0271
Major facilitator superfamily MFS_1; COGs: COG2814 Arabinose efflux permease; InterPro IPR011701:IPR016196; KEGG: cgt:cgR_2515 hypothetical protein; PFAM: major facilitator superfamily MFS_1; SPTR: A4QH10 Putative uncharacterized protein; PFAM: Major Facilitator Superfamily.
       0.780
Arch_0184
Exodeoxyribonuclease III Xth; COGs: COG0708 Exonuclease III; InterPro IPR005135:IPR004808; KEGG: jde:Jden_2428 exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase; SPTR: D0WLN3 Exodeoxyribonuclease III; TIGRFAM: exodeoxyribonuclease III Xth; PFAM: Endonuclease/Exonuclease/phosphatase family; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III (xth).
    
 0.718
Arch_1274
Exodeoxyribonuclease III Xth; COGs: COG0708 Exonuclease III; InterPro IPR004808:IPR005135; KEGG: jde:Jden_0698 exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase; SPTR: D0WNQ6 Exodeoxyribonuclease III; TIGRFAM: exodeoxyribonuclease III Xth; PFAM: Endonuclease/Exonuclease/phosphatase family; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III (xth).
    
 0.718
Arch_0272
Major facilitator superfamily MFS_1; InterPro IPR011701:IPR016196:IPR005829; KEGG: smt:Smal_1070 major facilitator superfamily MFS_1; PFAM: major facilitator superfamily MFS_1; SPTR: D0XPS3 Major facilitator superfamily MFS_1; PFAM: Sugar (and other) transporter; Major Facilitator Superfamily.
       0.678
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
  
 0.677
Arch_1079
formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
  
  
 0.666
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
 
   
0.611
recO
DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination.
     
 0.575
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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