STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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[Homology]
Score
Arch_0284COGs: COG0318 Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; InterPro IPR000873; KEGG: bcv:Bcav_3247 O-succinylbenzoic acid--CoA ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: D0WMF4 O-succinylbenzoate--CoA ligase; PFAM: AMP-binding enzyme. (379 aa)    
Predicted Functional Partners:
menB
Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
 
 
 0.995
menC
Mandelate racemase/muconate lactonizing protein; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
 
 
  0.975
menA
1,4-dihydroxy-2-naphthoateoctaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily.
 
   
 0.947
menD
2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylic-acid synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily.
 
  
 0.900
Arch_0286
Methyltransferase type 11; InterPro IPR013216; KEGG: bcv:Bcav_2129 methyltransferase type 12; PFAM: Methyltransferase type 11; SPTR: C4DS37 Methyltransferase family protein; PFAM: Thiopurine S-methyltransferase (TPMT).
     
 0.787
Arch_0282
KEGG: xce:Xcel_0448 hypothetical protein; SPTR: D0WMF2 Putative membrane protein.
  
    0.652
Arch_0290
COGs: COG1169 Isochorismate synthase; InterPro IPR015890:IPR005801:IPR004561; KEGG: bcv:Bcav_3233 isochorismate synthase; PFAM: Chorismate binding-like; SPTR: C5C0T1 Isochorismate synthase; TIGRFAM: isochorismate synthase; PFAM: chorismate binding enzyme; TIGRFAM: isochorismate synthases.
 
   
 0.637
Arch_1361
COGs: COG0318 Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; InterPro IPR000873:IPR017871; KEGG: ele:Elen_1832 AMP-dependent synthetase and ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: D0WP04 CoA ligase; PFAM: AMP-binding enzyme.
  
     0.609
rplF
Ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family.
    
  0.603
Arch_0547
AMP-dependent synthetase and ligase; COGs: COG1022 Long-chain acyl-CoA synthetase (AMP-forming); InterPro IPR020845:IPR000873; KEGG: jde:Jden_0962 AMP-dependent synthetase and ligase; PFAM: AMP-dependent synthetase and ligase; SPTR: D0WRA5 Putative CoA ligase; PFAM: AMP-binding enzyme.
 
 
 0.532
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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