STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
sbcDNuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (395 aa)    
Predicted Functional Partners:
Arch_0319
SMC domain protein; COGs: COG0419 ATPase involved in DNA repair; InterPro IPR001412:IPR003395; KEGG: cms:CMS_2145 putative nuclease; PFAM: SMC domain protein; SPTR: D0WRP2 Putative nuclease sbcCD subunit C; TIGRFAM: DNA sulfur modification protein DndD; exonuclease SbcC.
 
 0.999
Arch_0393
UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR002121:IPR014016:IPR014017:IPR000212; KEGG: bcv:Bcav_2897 UvrD/REP helicase; PFAM: UvrD/REP helicase; HRDC domain protein; SMART: HRDC domain protein; SPTR: D0WRX3 ATP-dependent DNA helicase II; PFAM: HRDC domain; UvrD/REP helicase.
  
 0.982
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.976
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.843
Arch_0782
SNF2-related protein; COGs: COG0553 Superfamily II DNA/RNA helicase SNF2 family; InterPro IPR014001:IPR001650:IPR014021:IPR000330; KEGG: bfa:Bfae_05330 DNA/RNA helicase, superfamily II, SNF2 family; PFAM: SNF2-related protein; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein; SPTR: C7MHJ1 DNA/RNA helicase, superfamily II, SNF2 family; PFAM: Helicase conserved C-terminal domain; SNF2 family N-terminal domain.
  
 
 0.773
Arch_0655
Helicase c2; COGs: COG1199 Rad3-related DNA helicase; InterPro IPR014001:IPR006555:IPR014013; KEGG: xce:Xcel_1256 helicase C2; SMART: helicase c2; DEAD-like helicase; SPTR: D0WQY5 ATP-dependent helicase DinG.
   
 0.754
Arch_1036
Sulphate transporter; COGs: COG0659 Sulfate permease and related transporter (MFS superfamily); InterPro IPR002645:IPR006162:IPR011547; KEGG: gbr:Gbro_3908 sulphate transporter; PFAM: sulphate transporter; Sulfate transporter/antisigma-factor antagonist STAS; SPTR: D0L3T1 Sulphate transporter; PFAM: Sulfate transporter family; STAS domain; TIGRFAM: high affinity sulphate transporter 1.
  
   0.752
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 0.714
Arch_1702
COGs: COG2812 DNA polymerase III gamma/tau subunits; KEGG: xce:Xcel_0355 DNA polymerase III, delta prime subunit; SPTR: D1BVC3 DNA polymerase III, delta prime subunit; PFAM: ATPase family associated with various cellular activities (AAA); TIGRFAM: DNA polymerase III, delta' subunit.
 
 0.712
Arch_1685
InterPro IPR005094; KEGG: lxx:Lxx07700 mobilization protein; PFAM: Relaxase/mobilization nuclease family protein; SPTR: C2BRG6 Possible mobilization protein; PFAM: Relaxase/Mobilisation nuclease domain.
   
 
 0.667
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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