STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Arch_0334RNA polymerase, sigma-24 subunit, ECF subfamily; COGs: COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog; InterProIPR000838:IPR007627:IPR013249:IPR014293:IPR 014284:IPR013325:IPR013324; KEGG: bcv:Bcav_1265 RNA polymerase, sigma-24 subunit, ECF subfamily; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; SPTR: D0WRQ2 RNA polymerase sigma-70 factor; TIGRFAM: RNA polymerase sigma-70 factor; RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70, region 4; Sigma-70 region 2; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; RNA polymer [...] (201 aa)    
Predicted Functional Partners:
rpoC
DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.992
rpoB
DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.992
Arch_0335
Anti-sigma factor; InterPro IPR014295; KEGG: cdi:DIP0710 putative anti sigma factor; SPTR: D0WRQ3 Anti-sigma factor RshA; TIGRFAM: anti-sigma factor; TIGRFAM: anti-sigma factor, TIGR02949 family.
  
 
 0.953
rpoZ
DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
    
 
 0.855
rpoA
DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.855
sigA
RNA polymerase, sigma 70 subunit, RpoD subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
   
  
 0.800
Arch_1810
COGs: COG0492 Thioredoxin reductase; InterPro IPR008255:IPR000103:IPR013027:IPR005982; KEGG: bfa:Bfae_31890 thioredoxin-disulfide reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: D0WL35 Thioredoxin-disulfide reductase; TIGRFAM: thioredoxin reductase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: thioredoxin-disulfide reductase.
     
 0.641
Arch_0102
COGs: COG0515 Serine/threonine protein kinase; InterProIPR020635:IPR002290:IPR005543:IPR017442:IPR 005503:IPR000719:IPR011009:IPR017441:IPR008271; KEGG: xce:Xcel_0018 serine/threonine protein kinase with PASTA sensor(s); PFAM: Serine/threonine-protein kinase-like domain; flagellar basal body-associated protein FliL; PASTA domain containing protein; SMART: serine/threonine protein kinase; Tyrosine-protein kinase, subgroup, catalytic domain; PASTA domain containing protein; SPTR: D0WKX3 Putative serine/threonine protein kinase; PFAM: Protein kinase domain; PASTA domain.
   
 
 0.584
Arch_0754
Serine/threonine protein kinase with PASTA sensor(s); COGs: COG2815 conserved hypothetical protein; InterProIPR011009:IPR008271:IPR020635:IPR002290:IPR 005543:IPR000719:IPR017442; KEGG: bcv:Bcav_1908 serine/threonine protein kinase with PASTA sensor(s); PFAM: Serine/threonine-protein kinase-like domain; PASTA domain containing protein; SMART: serine/threonine protein kinase; Tyrosine-protein kinase, subgroup, catalytic domain; PASTA domain containing protein; SPTR: A7BDG0 Putative uncharacterized protein; PFAM: Protein kinase domain; PASTA domain.
   
 
 0.584
Arch_0828
(p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
  
  
 0.520
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.