STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Arch_0411COGs: COG3920 Signal transduction histidine kinase; InterPro IPR003594:IPR005467:IPR013656:IPR011495; KEGG: bcv:Bcav_2829 signal transduction histidine kinase; PFAM: histidine kinase dimerisation/phosphoacceptor; PAS fold-4 domain protein; ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein; SPTR: D0WS29 Sensor histidine kinase; PFAM: Histidine kinase; Signal transduction histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; PAS fold; TIGRFAM: PAS domain S-box. (474 aa)    
Predicted Functional Partners:
Arch_0898
Response regulator receiver and ANTAR domain protein; COGs: COG3707 Response regulator with putative antiterminator output domain; InterProIPR011006:IPR001789:IPR008327:IPR005561:IPR 011991; KEGG: bfa:Bfae_14950 response regulator with putative antiterminator output domain; PFAM: response regulator receiver; ANTAR domain protein; SMART: response regulator receiver; SPTR: D0WMQ2 Two-component system response regulator; PFAM: Response regulator receiver domain; ANTAR domain.
 
   
 0.886
Arch_0410
Protein of unknown function DUF2505; InterPro IPR019639; KEGG: bcv:Bcav_2830 hypothetical protein; PFAM: Protein of unknown function DUF2505; SPTR: D0WS28 Putative uncharacterized protein; PFAM: Protein of unknown function (DUF2505).
       0.660
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
       0.619
Arch_0408
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
       0.618
Arch_0407
COGs: COG2808 Transcriptional regulator; InterPro IPR007396; KEGG: bvi:Bcep1808_3517 negative transcriptional regulator; PFAM: Negative transcriptional regulator; SPTR: C1WYZ0 Transcriptional regulator, COG2808; PFAM: Putative FMN-binding domain.
       0.566
Arch_1795
MATE efflux family protein; COGs: COG0534 Na+-driven multidrug efflux pump; InterPro IPR002528; KEGG: bcv:Bcav_4176 MATE efflux family protein; PFAM: multi antimicrobial extrusion protein MatE; SPTR: D0WL60 MATE efflux family protein; TIGRFAM: MATE efflux family protein; PFAM: MatE; TIGRFAM: putative efflux protein, MATE family.
  
   
 0.458
whiB
Transcription factor WhiB; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.
  
   
 0.434
Arch_1118
KEGG: bcv:Bcav_2744 hypothetical protein; SPTR: D0WNJ1 Putative uncharacterized protein; PFAM: Protein of unknown function (DUF3039).
  
     0.425
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.