STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Arch_0426Protein of unknown function DUF1212; COGs: COG2966 conserved hypothetical protein; InterPro IPR010619; KEGG: rmu:RMDY18_06380 hypothetical protein; PFAM: protein of unknown function DUF1212; SPTR: C0W2A9 Putative uncharacterized protein; PFAM: Protein of unknown function (DUF1212). (441 aa)    
Predicted Functional Partners:
Arch_0754
Serine/threonine protein kinase with PASTA sensor(s); COGs: COG2815 conserved hypothetical protein; InterProIPR011009:IPR008271:IPR020635:IPR002290:IPR 005543:IPR000719:IPR017442; KEGG: bcv:Bcav_1908 serine/threonine protein kinase with PASTA sensor(s); PFAM: Serine/threonine-protein kinase-like domain; PASTA domain containing protein; SMART: serine/threonine protein kinase; Tyrosine-protein kinase, subgroup, catalytic domain; PASTA domain containing protein; SPTR: A7BDG0 Putative uncharacterized protein; PFAM: Protein kinase domain; PASTA domain.
 
     0.584
Arch_0102
COGs: COG0515 Serine/threonine protein kinase; InterProIPR020635:IPR002290:IPR005543:IPR017442:IPR 005503:IPR000719:IPR011009:IPR017441:IPR008271; KEGG: xce:Xcel_0018 serine/threonine protein kinase with PASTA sensor(s); PFAM: Serine/threonine-protein kinase-like domain; flagellar basal body-associated protein FliL; PASTA domain containing protein; SMART: serine/threonine protein kinase; Tyrosine-protein kinase, subgroup, catalytic domain; PASTA domain containing protein; SPTR: D0WKX3 Putative serine/threonine protein kinase; PFAM: Protein kinase domain; PASTA domain.
 
     0.559
lspA
Lipoprotein signal peptidase; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family.
     
 0.537
tilS
tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family.
  
    0.521
nhaA
Na+/H+ antiporter NhaA; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
     
 0.515
Arch_0425
Methyltransferase type 11; COGs: COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis; InterPro IPR013216; KEGG: art:Arth_2657 methyltransferase type 11; PFAM: Methyltransferase type 11; SPTR: A7BAJ7 Putative uncharacterized protein; PFAM: Methyltransferase domain.
  
    0.515
Arch_0859
Fmu (Sun) domain protein; COGs: COG0144 tRNA and rRNA cytosine-C5-methylase; InterPro IPR006027:IPR001678; KEGG: jde:Jden_1312 Fmu (Sun) domain protein; PFAM: Fmu (Sun) domain protein; NusB/RsmB/TIM44; SPTR: D0WMY6 Ribosomal RNA small subunit methyltransferase B; PFAM: NOL1/NOP2/sun family; NusB family; TIGRFAM: ribosomal RNA small subunit methyltransferase RsmB; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
  
    0.511
obg
GTP-binding protein Obg/CgtA; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
  
    0.511
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.497
Arch_0096
Peptidylprolyl isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.
       0.493
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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