close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Arch_0435Transcriptional regulator, LacI family; COGs: COG1609 Transcriptional regulators; InterPro IPR000843:IPR001761:IPR010982; KEGG: pac:PPA2330 LacI family transcription regulator; PFAM: regulatory protein LacI; periplasmic binding protein/LacI transcriptional regulator; SMART: regulatory protein LacI; SPTR: D0YQM2 LacI family transcription regulator; PFAM: Bacterial regulatory proteins, lacI family; family. (335 aa)    
Predicted Functional Partners:
Arch_0433
Alanine racemase domain protein; COGs: COG0325 enzyme with a TIM-barrel fold; InterPro IPR001608:IPR011078; KEGG: eba:ebA1768 hypothetical protein; PFAM: alanine racemase domain protein; SPTR: D0WRH4 Pyridoxal phosphate enzyme, YggS family; PFAM: Alanine racemase, N-terminal domain; TIGRFAM: pyridoxal phosphate enzyme, YggS family.
  
    0.774
Arch_0434
DEAD/DEAH box helicase domain protein; COGs: COG4581 Superfamily II RNA helicase; InterPro IPR014021:IPR001650:IPR011545:IPR014001; KEGG: nfa:nfa37840 putative helicase; PFAM: DEAD/DEAH box helicase domain protein; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein; SPTR: D0WRH3 Putative ATP-dependent helicase; PFAM: Domain of unknown function (DUF3516); Helicase conserved C-terminal domain; DEAD/DEAH box helicase.
       0.773
Arch_1478
Transcriptional regulator, LacI family; COGs: COG1609 Transcriptional regulators; InterPro IPR000843:IPR010982; KEGG: sco:SCO5692 transcriptional regulator; PFAM: regulatory protein LacI; SMART: regulatory protein LacI; SPTR: C0W8S7 Regulatory protein LacI family protein; PFAM: Bacterial regulatory proteins, lacI family; family.
  
     0.770
Arch_1488
Transcriptional regulator, LacI family; COGs: COG1609 Transcriptional regulators; InterPro IPR000843:IPR010982; KEGG: sth:STH770 LacI family transcriptional repressor; PFAM: regulatory protein LacI; SMART: regulatory protein LacI; SPTR: C0W1U4 Putative uncharacterized protein; PFAM: Bacterial regulatory proteins, lacI family.
  
     0.761
Arch_0436
COGs: COG1904 Glucuronate isomerase; InterPro IPR003766; KEGG: art:Arth_0502 glucuronate isomerase; PFAM: Glucuronate isomerase; PRIAM: Glucuronate isomerase; SPTR: D0YQL1 Glucuronate isomerase; PFAM: Glucuronate isomerase.
 
  
 0.745
Arch_0437
PfkB domain protein; COGs: COG0524 Sugar kinase ribokinase family; InterPro IPR011611; KEGG: xce:Xcel_0908 PfkB domain protein; PFAM: PfkB domain protein; SPTR: D0YQL2 Carbohydrate kinase; PFAM: pfkB family carbohydrate kinase.
 
  
 0.481
Arch_1122
Dihydroxyacetone kinase, phosphotransfer subunit; COGs: COG3412 conserved hypothetical protein; InterProIPR000032:IPR004701:IPR012844:IPR005698:IPR 001020; KEGG: ecm:EcSMS35_4856 phosphoenolpyruvate-protein phosphotransferase PtnE; PFAM: PTS system fructose subfamily IIA component; phosphoryl transfer system HPr; SPTR: D0YPG5 PTS-dependent dihydroxyacetone kinase, DhaM subunit; TIGRFAM: dihydroxyacetone kinase, phosphotransfer subunit; phosphocarrier, HPr family; PFAM: PTS system fructose IIA component; PTS HPr component phosphorylation site; TIGRFAM: dihydroxyacetone kinase, phosphotr [...]
   
 
 0.462
Arch_1461
COGs: COG1925 Phosphotransferase system HPr-related protein; InterPro IPR000032:IPR005698:IPR001020; KEGG: cef:CE1830 putative PTS phosphohistidine-containing protein; PFAM: phosphoryl transfer system HPr; SPTR: A7BEU7 Putative uncharacterized protein; TIGRFAM: phosphocarrier, HPr family; PFAM: PTS HPr component phosphorylation site; TIGRFAM: Phosphotransferase System HPr (HPr) Family.
   
 
 0.459
Arch_0438
COGs: COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase; InterPro IPR013785:IPR000887; KEGG: tau:Tola_0229 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase; PFAM: KDPG and KHG aldolase; SPTR: D0YQL3 Khg/kdpg aldolase; TIGRFAM: 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase; PFAM: KDPG and KHG aldolase; TIGRFAM: Entner-Doudoroff aldolase.
 
  
 0.458
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
    
   0.429
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.