STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Arch_0448Exonuclease RNase T and DNA polymerase III; 3'-to-5' exoribonuclease specific for small oligoribonucleotides. (218 aa)    
Predicted Functional Partners:
rnj
RNA-metabolising metallo-beta-lactamase; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
      
 0.770
Arch_1806
Polynucleotide adenylyltransferase/metal dependent phosphohydrolase; COGs: COG0617 tRNA nucleotidyltransferase/poly(A) polymerase; InterProIPR003607:IPR002646:IPR006674:IPR014065:IPR 006675; KEGG: jde:Jden_2542 polynucleotide adenylyltransferase/metal dependent phosphohydrolase; PFAM: Polynucleotide adenylyltransferase region; metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; SPTR: D0WL39 tRNA adenylyltransferase; TIGRFAM: tRNA adenylyltransferase; metal dependent phophohydrolase; manually curated; PFAM: HD domain; Poly A polymerase head [...]
 
   
 0.633
rph
Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
   
  
 0.550
pnp
Guanosine pentaphosphate synthetase I/polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.
      
 0.517
Arch_0449
KEGG: bcv:Bcav_2645 putative transcriptional regulator, TetR family; SPTR: D0WRE6 Putative ATP/GTP-binding protein; PFAM: Dynamin family.
       0.515
Arch_1072
Ribonuclease, Rne/Rng family; COGs: COG1530 Ribonuclease G and E; InterProIPR016027:IPR004659:IPR003029:IPR012340:IPR 019307; KEGG: bcv:Bcav_1618 ribonuclease, Rne/Rng family; PFAM: RNA-binding protein AU-1/Ribonuclease E/G; RNA binding S1 domain protein; SPTR: D0WNB8 Putative S1 RNA binding domain protein; TIGRFAM: ribonuclease, Rne/Rng family; PFAM: Ribonuclease E/G family; S1 RNA binding domain; TIGRFAM: ribonuclease, Rne/Rng family.
  
  
 0.515
Arch_0451
Single-strand binding protein; InterPro IPR012340:IPR000424:IPR011344:IPR016027; KEGG: ach:Achl_2173 single-strand binding protein; PFAM: single-strand binding protein/Primosomal replication protein n; SPTR: D0WRE4 Single-stranded DNA-binding protein 1; TIGRFAM: single-strand binding protein; PFAM: Single-strand binding protein family; TIGRFAM: single stranded DNA-binding protein (ssb).
  
 
 0.505
Arch_0127
COGs: COG1643 HrpA-like helicase; InterProIPR014001:IPR003593:IPR001650:IPR007502:IPR 011709:IPR014021:IPR010222; KEGG: jde:Jden_0240 ATP-dependent helicase HrpA; PFAM: helicase-associated domain protein; helicase domain protein; protein of unknown function DUF1605; SMART: DEAD-like helicase; AAA ATPase; helicase domain protein; SPTR: D0WKL4 ATP-dependent helicase HrpA; TIGRFAM: ATP-dependent helicase HrpA; PFAM: Helicase conserved C-terminal domain; Helicase associated domain (HA2); Domain of unknown function (DUF3418); Domain of unknown function (DUF1605); TIGRFAM: ATP-dependent heli [...]
 
  
 0.495
infC
Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
      
 0.453
Arch_0450
Hypothetical protein; KEGG: bcv:Bcav_2644 ATP-binding membrane protein; SPTR: D0WRE5 Putative ATP-binding membrane protein; PFAM: Elongation factor Tu GTP binding domain.
       0.451
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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