STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Arch_0476COGs: COG1045 Serine acetyltransferase; InterPro IPR018357:IPR001451:IPR005881:IPR011004; KEGG: mlu:Mlut_09440 serine O-acetyltransferase; SPTR: D0WRD0 Serine O-acetyltransferase; TIGRFAM: serine O-acetyltransferase; PFAM: Serine acetyltransferase, N-terminal; TIGRFAM: serine O-acetyltransferase. (193 aa)    
Predicted Functional Partners:
Arch_0477
COGs: COG0031 Cysteine synthase; InterPro IPR001216:IPR001926:IPR005856:IPR005859; KEGG: xce:Xcel_1111 cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: D0WRC9 Cysteine synthase A; TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; Belongs to the cysteine synthase/cystathionine beta- synthase family.
 
 0.999
cysS
COGs: COG0215 Cysteinyl-tRNA synthetase; InterProIPR009080:IPR015803:IPR015273:IPR002308:IPR 014729; KEGG: bcv:Bcav_0780 cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase class Ia; Cysteinyl-tRNA synthetase class Ia DALR; PRIAM: Cysteine--tRNA ligase; SPTR: D0WJY3 Cysteine--tRNA ligase; TIGRFAM: cysteinyl-tRNA synthetase; PFAM: tRNA synthetases class I (C) catalytic domain; DALR domain; TIGRFAM: cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
  
 0.971
Arch_0812
COGs: COG1760 L-serine deaminase; InterPro IPR004644:IPR005131:IPR005130; KEGG: aau:AAur_3830 L-serine ammonia-lyase; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; PRIAM: L-serine ammonia-lyase; SPTR: A1RB97 L-serine ammonia-lyase; TIGRFAM: L-serine dehydratase 1; PFAM: Serine dehydratase alpha chain; Serine dehydratase beta chain; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, single chain form.
     
 0.912
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.886
Arch_0352
COGs: COG0083 Homoserine kinase; InterPro IPR014721:IPR020568; KEGG: cai:Caci_1201 homoserine kinase; SPTR: D0WRS3 Homoserine kinase.
     
 0.827
Arch_0478
Protein of unknown function UPF0029; COGs: COG1739 conserved hypothetical protein; InterPro IPR020569:IPR001498:IPR015269:IPR020568; KEGG: cur:cur_1185 hypothetical protein; PFAM: protein of unknown function UPF0029; Domain of unknown function DUF1949; SPTR: D0WRC8 IMPACT family member YigZ; PFAM: Uncharacterized protein family UPF0029; TIGRFAM: conserved hypothetical protein TIGR00257.
       0.550
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
     
 0.524
Arch_1240
ATPase-like, ParA/MinD; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family.
  
  
 0.471
Arch_0071
COGs: COG1216 glycosyltransferase; InterPro IPR001173:IPR001296; KEGG: nml:Namu_4203 glycosyl transferase family 2; PFAM: glycosyl transferase family 2; glycosyl transferase group 1; SPTR: C1RIN5 Predicted glycosyltransferase (Fragment); PFAM: Glycosyl transferases group 1; Glycosyl transferase family 2; TIGRFAM: glutamate--cysteine ligase/gamma-glutamylcysteine synthetase, Streptococcus agalactiae type.
  
  
 0.414
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
     
 0.409
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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