STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Arch_0477COGs: COG0031 Cysteine synthase; InterPro IPR001216:IPR001926:IPR005856:IPR005859; KEGG: xce:Xcel_1111 cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: D0WRC9 Cysteine synthase A; TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; Belongs to the cysteine synthase/cystathionine beta- synthase family. (308 aa)    
Predicted Functional Partners:
Arch_0476
COGs: COG1045 Serine acetyltransferase; InterPro IPR018357:IPR001451:IPR005881:IPR011004; KEGG: mlu:Mlut_09440 serine O-acetyltransferase; SPTR: D0WRD0 Serine O-acetyltransferase; TIGRFAM: serine O-acetyltransferase; PFAM: Serine acetyltransferase, N-terminal; TIGRFAM: serine O-acetyltransferase.
 
 0.999
Arch_1404
Aminotransferase class I and II; COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterProIPR004839:IPR015421:IPR015424:IPR001176:IPR 004838; KEGG: bcv:Bcav_3164 aminotransferase class I and II; PFAM: aminotransferase class I and II; SPTR: D0WPG0 Aspartate transaminase; PFAM: Aminotransferase class I and II.
  
 0.932
luxS
Quorum-sensing autoinducer 2 (AI-2), LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
  
 
 0.886
cysS
COGs: COG0215 Cysteinyl-tRNA synthetase; InterProIPR009080:IPR015803:IPR015273:IPR002308:IPR 014729; KEGG: bcv:Bcav_0780 cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase class Ia; Cysteinyl-tRNA synthetase class Ia DALR; PRIAM: Cysteine--tRNA ligase; SPTR: D0WJY3 Cysteine--tRNA ligase; TIGRFAM: cysteinyl-tRNA synthetase; PFAM: tRNA synthetases class I (C) catalytic domain; DALR domain; TIGRFAM: cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 
 0.879
pepA
Peptidase M17 leucyl aminopeptidase domain protein; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.
   
 0.834
Arch_0855
Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family.
    
  0.823
Arch_0473
COGs: COG0308 Aminopeptidase N; InterPro IPR014782:IPR012778; KEGG: bcv:Bcav_2630 aminopeptidase N; PFAM: Peptidase M1 membrane alanine aminopeptidase; SPTR: D0WRD5 Aminopeptidase; TIGRFAM: aminopeptidase N; PFAM: Domain of unknown function (DUF3358); Peptidase family M1; TIGRFAM: aminopeptidase N, Streptomyces lividans type.
    
 0.814
Arch_0872
COGs: COG0308 Aminopeptidase N; InterPro IPR014782:IPR016059:IPR012778; KEGG: kse:Ksed_24070 aminopeptidase N; PFAM: Peptidase M1 membrane alanine aminopeptidase; SPTR: C7NFC1 Aminopeptidase N; TIGRFAM: aminopeptidase N; PFAM: Peptidase family M1; Domain of unknown function (DUF3358); TIGRFAM: aminopeptidase N, Streptomyces lividans type.
    
 0.814
Arch_1250
thiamineS protein; InterPro IPR016155:IPR012675:IPR003749; KEGG: fre:Franean1_6174 thiamineS protein; PFAM: thiamineS protein; SPTR: D0WL89 Molybdopterin converting factor, subunit 1; PFAM: ThiS family.
  
 
 0.722
Arch_0478
Protein of unknown function UPF0029; COGs: COG1739 conserved hypothetical protein; InterPro IPR020569:IPR001498:IPR015269:IPR020568; KEGG: cur:cur_1185 hypothetical protein; PFAM: protein of unknown function UPF0029; Domain of unknown function DUF1949; SPTR: D0WRC8 IMPACT family member YigZ; PFAM: Uncharacterized protein family UPF0029; TIGRFAM: conserved hypothetical protein TIGR00257.
   
   0.622
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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