STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Arch_0526Two component transcriptional regulator, LuxR family; COGs: COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; InterProIPR011991:IPR001789:IPR013249:IPR000792:IPR 011006; KEGG: kra:Krad_4263 two component transcriptional regulator, LuxR family; PFAM: response regulator receiver; Sigma-70 region 4 type 2; SMART: response regulator receiver; regulatory protein LuxR; SPTR: D0YQC0 Two component LuxR family transcriptional regulator; PFAM: Response regulator receiver domain; Bacterial regulatory proteins, luxR family. (219 aa)    
Predicted Functional Partners:
Arch_0527
COGs: COG4585 Signal transduction histidine kinase; InterPro IPR003594; KEGG: cai:Caci_0638 histidine kinase; PFAM: ATP-binding region ATPase domain protein; SPTR: C2KNP1 Histidine kinase.
 
 
 0.905
Arch_0416
COGs: COG4585 Signal transduction histidine kinase; InterPro IPR003594:IPR011712; KEGG: bcv:Bcav_2821 histidine kinase; PFAM: histidine kinase dimerisation and phosphoacceptor region; ATP-binding region ATPase domain protein; SPTR: D0WS36 Putative signal transduction histidine kinase; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
 
 
 0.867
Arch_0530
Histidine kinase; COGs: COG4585 Signal transduction histidine kinase; InterPro IPR011712:IPR003594; KEGG: kse:Ksed_07210 histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase dimerisation and phosphoacceptor region; SPTR: D0WNH3 Sensor histidine kinase; manually curated; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
 
 
 0.858
Arch_1603
COGs: COG4585 Signal transduction histidine kinase; InterPro IPR003594:IPR011712; KEGG: kse:Ksed_01000 signal transduction histidine kinase; PFAM: histidine kinase dimerisation and phosphoacceptor region; ATP-binding region ATPase domain protein; SPTR: C2BTB8 Two component system histidine kinase; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
 
 
 0.854
Arch_0528
KEGG: oan:Oant_1198 BioY protein.
       0.773
Arch_0529
Two component transcriptional regulator, LuxR family; COGs: COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; InterProIPR011991:IPR000792:IPR001789:IPR011006:IPR 016032; KEGG: ckp:ckrop_0504 two-component system, response regulator; PFAM: response regulator receiver; regulatory protein LuxR; SMART: regulatory protein LuxR; response regulator receiver; SPTR: D0WNH1 Two-component system response regulator; PFAM: Response regulator receiver domain; Bacterial regulatory proteins, luxR family.
  
     0.769
Arch_1077
COGs: COG4585 Signal transduction histidine kinase; InterPro IPR003594:IPR003018:IPR011712; KEGG: bcv:Bcav_1613 GAF sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; GAF domain protein; histidine kinase dimerisation and phosphoacceptor region; SMART: GAF domain protein; ATP-binding region ATPase domain protein; SPTR: D0WNC3 Putative two-component sensor; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain.
 
 
 0.562
Arch_1283
COGs: COG4585 Signal transduction histidine kinase; InterPro IPR003594; KEGG: bcv:Bcav_3034 putative signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; SPTR: C0W6Q0 Signal transduction histidine kinase; PFAM: PspC domain.
  
 
 0.484
Arch_1722
Transcriptional regulator, Crp/Fnr family; COGs: COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase; InterProIPR000595:IPR001808:IPR018490:IPR012318:IPR 014710:IPR011991; KEGG: sgr:SGR_3333 Crp/Fnr family transcriptional regulator; PFAM: cyclic nucleotide-binding; regulatory protein Crp; SMART: cyclic nucleotide-binding; regulatory protein Crp; SPTR: D0WK55 Transcriptional regulator, Crp/Fnr family; PFAM: Bacterial regulatory proteins, crp family; Cyclic nucleotide-binding domain.
  
 
 0.405
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.