STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Arch_0660UvrD/REP helicase; COGs: COG3973 Superfamily I DNA and RNA helicase; InterPro IPR014016:IPR000212; KEGG: bcv:Bcav_2428 ATP-dependent DNA helicase; PFAM: UvrD/REP helicase; SPTR: D0WQX3 Putative DNA or RNA helicase, Superfamily I; PFAM: UvrD/REP helicase. (751 aa)    
Predicted Functional Partners:
rpoB
DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.873
rpoC
DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.871
sigA
RNA polymerase, sigma 70 subunit, RpoD subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
    
   0.846
rpoZ
DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
  
 
   0.845
rpoA
DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
   0.845
rbpA
Hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.
  
 
   0.709
Arch_0661
Protein of unknown function DUF75; InterPro IPR002766; KEGG: tfu:Tfu_0926 hypothetical protein; PFAM: protein of unknown function DUF75; SPTR: D0WQX2 Putative uncharacterized protein; PFAM: PAC2 family.
 
     0.617
Arch_0659
COGs: COG0318 Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; InterPro IPR018062:IPR020845:IPR000873; KEGG: saq:Sare_2221 acyl-CoA synthetase; PFAM: AMP-dependent synthetase and ligase; SPTR: D0WQX6 CoA ligase; PFAM: AMP-binding enzyme.
       0.587
Arch_0904
InterPro IPR004989:IPR004347; KEGG: bcv:Bcav_2240 protein of unknown function DUF245 domain protein; PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; SPTR: D0WMP2 Proteasome accessory factor PafA2; PFAM: Pup-ligase protein.
  
     0.469
Arch_1632
KEGG: bcv:Bcav_0815 hypothetical protein; SPTR: D0WJU8 Putative uncharacterized protein.
  
     0.448
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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