STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Arch_0731Phosphoglycerate mutase; COGs: COG0406 Fructose-2 6-bisphosphatase; InterPro IPR001345:IPR013078; KEGG: aau:AAur_3898 phosphoglycerate mutase family protein; PFAM: Phosphoglycerate mutase; SPTR: A1RBG3 Phosphoglycerate mutase family protein; PFAM: Phosphoglycerate mutase family. (200 aa)    
Predicted Functional Partners:
Arch_0729
COGs: COG0174 Glutamine synthetase; InterPro IPR008147:IPR008146:IPR014746; KEGG: jde:Jden_1487 glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; SPTR: D0WQP4 Glutamate--ammonia ligase; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I.
  
    0.817
Arch_0730
(Glutamate--ammonia-ligase) adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tra [...]
       0.817
panB
3-methyl-2-oxobutanoatehydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
       0.517
Arch_0726
Polyphosphate--glucose phosphotransferase; COGs: COG1940 Transcriptional regulator/sugar kinase; InterPro IPR000600; KEGG: xce:Xcel_2049 ROK family protein; PFAM: ROK family protein; PRIAM: Polyphosphate--glucose phosphotransferase; SPTR: D1BFU6 Polyphosphate glucokinase; PFAM: ROK family.
 
   
 0.515
map
Methionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
     
 0.513
Arch_1121
COGs: COG0627 esterase; InterPro IPR000801; KEGG: cgt:cgR_1064 hypothetical protein; PFAM: putative esterase; SPTR: C2KS46 Esterase; PFAM: Putative esterase.
  
     0.439
pgm
Phosphoglycerate mutase; COGs: COG0406 Fructose-2 6-bisphosphatase; InterPro IPR001345:IPR013078; KEGG: jde:Jden_1640 phosphoglycerate mutase; PFAM: Phosphoglycerate mutase; SPTR: C2BVI5 Possible phosphoglycerate mutase; PFAM: Phosphoglycerate mutase family.
  
   
 0.432
Arch_0290
COGs: COG1169 Isochorismate synthase; InterPro IPR015890:IPR005801:IPR004561; KEGG: bcv:Bcav_3233 isochorismate synthase; PFAM: Chorismate binding-like; SPTR: C5C0T1 Isochorismate synthase; TIGRFAM: isochorismate synthase; PFAM: chorismate binding enzyme; TIGRFAM: isochorismate synthases.
     
 0.406
prfA
Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
     
 0.405
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.