STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Arch_0732COGs: COG0174 Glutamine synthetase; InterPro IPR008147:IPR008146:IPR014746:IPR004809; KEGG: kra:Krad_3291 glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; SPTR: D0WQN7 Glutamine synthetase, type I; TIGRFAM: glutamine synthetase, type I; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I. (475 aa)    
Predicted Functional Partners:
Arch_0202
COGs: COG0334 Glutamate dehydrogenase/leucine dehydrogenase; InterProIPR006097:IPR006096:IPR016040:IPR014362:IPR 006095; KEGG: jde:Jden_2359 glutamate dehydrogenase (NADP(+)); PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; PRIAM: Glutamate dehydrogenase (NADP(+)); SPTR: C0W243 Glutamate dehydrogenase; PFAM: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.955
Arch_0730
(Glutamate--ammonia-ligase) adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tra [...]
 
  
 0.935
glmS
Glucosamine/fructose-6-phosphate aminotransferase, isomerizing; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
  
 
 0.926
Arch_0729
COGs: COG0174 Glutamine synthetase; InterPro IPR008147:IPR008146:IPR014746; KEGG: jde:Jden_1487 glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; SPTR: D0WQP4 Glutamate--ammonia ligase; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I.
 
  
0.923
carB
COGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterProIPR016185:IPR005480:IPR006275:IPR011761:IPR 005479:IPR013817:IPR013816:IPR005481:IPR011607:IPR005483; KEGG: gwc:GWCH70_1047 carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; MGS domain protein; SPTR: B6FK85 Putative uncharacterized protein; TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain, [...]
  
 
 0.916
Arch_1474
COGs: COG3303 Formate-dependent nitrite reductase periplasmic cytochrome c552 subunit; InterPro IPR003321:IPR011031; KEGG: mxa:MXAN_2209 putative cytochrome c nitrite reductase, catalytic subunit NrfA; PFAM: cytochrome c552; PRIAM: Nitrite reductase (cytochrome; ammonia-forming); SPTR: B4CX41 Nitrite reductase (Cytochrome; ammonia-forming); PFAM: Cytochrome c552; Belongs to the cytochrome c-552 family.
     
 0.904
Arch_1475
COGs: COG3005 Nitrate/TMAO reductase membrane-bound tetraheme cytochrome c subunit; InterPro IPR011031:IPR005126:IPR017571; KEGG: mxa:MXAN_2210 putative cytochrome c nitrite reductase, small subunit NrfH; PFAM: NapC/NirT cytochrome c domain protein; SPTR: Q1DA91 Putative cytochrome c nitrite reductase, small subunit NrfH; TIGRFAM: cytochrome c nitrate reductase, small subunit; PFAM: NapC/NirT cytochrome c family, N-terminal region; TIGRFAM: cytochrome c nitrate reductase, small subunit.
     
 0.900
Arch_0736
COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterProIPR013027:IPR000815:IPR016156:IPR012999:IPR 004099:IPR006258; KEGG: jde:Jden_1475 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; SPTR: D0WQM8 Dihydrolipoyl dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase.
  
 
 0.884
Arch_0178
Glutamyl/glutaminyl-tRNA synthetase, class Ic, catalytic domain protein; COGs: COG0008 Glutamyl- and glutaminyl-tRNA synthetase; InterPro IPR020058:IPR014729:IPR020060:IPR001412; KEGG: mgi:Mflv_1233 glutamyl-Q tRNA(Asp) synthetase; PFAM: Glutamyl/glutaminyl-tRNA synthetase, class Ic, catalytic domain; SPTR: D0WLH0 Glutamate--tRNA ligase; PFAM: tRNA synthetases class I (E and Q), catalytic domain; Belongs to the class-I aminoacyl-tRNA synthetase family.
    
 0.819
gluSR
glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
    
 0.819
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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