STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Arch_0766COGs: COG0188 Type IIA topoisomerase (DNA gyrase/topo II topoisomerase IV) A subunit; InterProIPR013760:IPR002205:IPR013758:IPR013757:IPR 006691; KEGG: bcv:Bcav_1928 DNA topoisomerase (ATP-hydrolyzing); PFAM: DNA gyrase/topoisomerase IV subunit A; DNA gyrase repeat beta-propeller; PRIAM: DNA topoisomerase (ATP-hydrolyzing); SMART: DNA gyrase/topoisomerase IV subunit A; SPTR: C5C5J3 DNA topoisomerase (ATP-hydrolyzing); PFAM: DNA gyrase/topoisomerase IV, subunit A; DNA gyrase C-terminal domain, beta-propeller. (804 aa)    
Predicted Functional Partners:
gyrB
DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
 
 
 0.985
Arch_0763
COGs: COG0187 Type IIA topoisomerase (DNA gyrase/topo II topoisomerase IV) B subunit; InterProIPR001241:IPR000565:IPR013760:IPR003594:IPR 020568:IPR018522:IPR013759:IPR013506:IPR006171:IPR002288; KEGG: bcv:Bcav_1922 DNA topoisomerase (ATP-hydrolyzing); PFAM: DNA topoisomerase type IIA subunit B region 2 domain protein; ATP-binding region ATPase domain protein; TOPRIM domain protein; DNA gyrase subunit B domain protein; PRIAM: DNA topoisomerase (ATP-hydrolyzing); SMART: DNA topoisomerase II; ATP-binding region ATPase domain protein; SPTR: D0WQJ3 Putative DNA gyrase subunit B; PFAM: Topr [...]
 
 
 0.977
Arch_0767
KEGG: nca:Noca_2946 hypothetical protein; SPTR: D0WQI8 Putative uncharacterized protein.
 
     0.649
Arch_0768
Type I phosphodiesterase/nucleotide pyrophosphatase; COGs: COG1524 Uncharacterized protein of the AP superfamily; InterPro IPR017850:IPR017849:IPR002591; KEGG: bcv:Bcav_1931 type I phosphodiesterase/nucleotide pyrophosphatase; PFAM: type I phosphodiesterase/nucleotide pyrophosphatase; SPTR: D0WQI7 Type I phosphodiesterase / nucleotide pyrophosphatase family protein; PFAM: Type I phosphodiesterase / nucleotide pyrophosphatase.
       0.613
Arch_0769
COGs: COG1435 Thymidine kinase; InterPro IPR001267; KEGG: bcv:Bcav_1932 thymidine kinase; PFAM: thymidine kinase; PRIAM: Thymidine kinase; SPTR: D0WQI6 Thymidine kinase; PFAM: Thymidine kinase.
     
 0.613
Arch_0006
COGs: COG0188 Type IIA topoisomerase (DNA gyrase/topo II topoisomerase IV) A subunit; InterProIPR002205:IPR006691:IPR013758:IPR013757:IPR 005743:IPR013760; KEGG: bcv:Bcav_0007 DNA gyrase, A subunit; PFAM: DNA gyrase/topoisomerase IV subunit A; DNA gyrase repeat beta-propeller; PRIAM: DNA topoisomerase (ATP-hydrolyzing); SMART: DNA gyrase/topoisomerase IV subunit A; SPTR: D0WL03 DNA gyrase, A subunit; TIGRFAM: DNA gyrase, A subunit; PFAM: DNA gyrase/topoisomerase IV, subunit A; DNA gyrase C-terminal domain, beta-propeller; TIGRFAM: DNA gyrase, A subunit.
  
  
 
0.609
tuf
Translation elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.
   
  
 0.600
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.566
pheT
COGs: COG0072 Phenylalanyl-tRNA synthetase beta subunit; InterProIPR020825:IPR005121:IPR016027:IPR009061:IPR 004532:IPR002547:IPR012340:IPR005147:IPR005146; KEGG: jde:Jden_1109 phenylalanyl-tRNA synthetase, beta subunit; PFAM: B3/4 domain protein; t-RNA-binding domain protein; tRNA synthetase B5; ferredoxin-fold anticodon-binding; SPTR: D0WN31 Phenylalanyl-tRNA synthetase, beta subunit; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; PFAM: tRNA synthetase B5 domain; B3/4 domain; Ferredoxin-fold anticodon binding domain; Putative tRNA binding domain; TIGRFAM: phenylalanyl-tRNA synt [...]
  
  
 0.561
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
  
 0.559
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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