STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Arch_07911-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase; COGs: COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase; InterPro IPR000031; KEGG: chy:CHY_1069 phosphoribosylaminoimidazole carboxylase, catalytic subunit; PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; SPTR: Q3AD69 Phosphoribosylaminoimidazole carboxylase, catalytic subunit; PFAM: AIR carboxylase. (88 aa)    
Predicted Functional Partners:
purC
COGs: COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; InterPro IPR001636:IPR013816:IPR010916; KEGG: mlu:Mlut_18500 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; PRIAM: Phosphoribosylaminoimidazolesuccinocarboxamide synthase; SPTR: D0WLR3 Phosphoribosylaminoimidazolesuccinocarboxamide synthase; PFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase.
  
 
 0.991
Arch_1177
COGs: COG0015 Adenylosuccinate lyase; InterProIPR008948:IPR004769:IPR020557:IPR000362:IPR 003031; KEGG: cth:Cthe_0741 adenylosuccinate lyase; PFAM: fumarate lyase; SPTR: C0ECV4 Putative uncharacterized protein; TIGRFAM: adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: adenylosuccinate lyase.
  
  
 0.912
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
 
   
 0.818
Arch_1179
COGs: COG0516 IMP dehydrogenase/GMP reductase; InterProIPR005991:IPR018529:IPR000644:IPR013785:IPR 001093; KEGG: sco:SCO1461 inosine 5-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; CBS domain containing protein; PRIAM: IMP dehydrogenase; SMART: CBS domain containing protein; SPTR: C0W4C2 Possible IMP dehydrogenase; TIGRFAM: IMP dehydrogenase family protein; PFAM: CBS domain; IMP dehydrogenase / GMP reductase domain; TIGRFAM: inosine-5'-monophosphate dehydrogenase; IMP dehydrogenase family protein.
  
  
 0.758
pyrB
COGs: COG0540 Aspartate carbamoyltransferase catalytic chain; InterPro IPR006130:IPR002082:IPR006132:IPR006131; KEGG: cpf:CPF_1387 aspartate carbamoyltransferase catalytic subunit; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; SPTR: C2KYS1 Aspartate carbamoyltransferase; TIGRFAM: aspartate carbamoyltransferase; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Aspartate carbamoyltransferase regulatory c [...]
  
  
 0.749
carB
COGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterProIPR016185:IPR005480:IPR006275:IPR011761:IPR 005479:IPR013817:IPR013816:IPR005481:IPR011607:IPR005483; KEGG: gwc:GWCH70_1047 carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; MGS domain protein; SPTR: B6FK85 Putative uncharacterized protein; TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain, [...]
 
  
 0.692
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
  
 0.675
dxs
Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.
  
  
 0.631
Arch_1025
Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
 
  
 0.600
recO
DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination.
  
  
 0.585
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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