STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Arch_0812COGs: COG1760 L-serine deaminase; InterPro IPR004644:IPR005131:IPR005130; KEGG: aau:AAur_3830 L-serine ammonia-lyase; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; PRIAM: L-serine ammonia-lyase; SPTR: A1RB97 L-serine ammonia-lyase; TIGRFAM: L-serine dehydratase 1; PFAM: Serine dehydratase alpha chain; Serine dehydratase beta chain; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, single chain form. (460 aa)    
Predicted Functional Partners:
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.987
Arch_0476
COGs: COG1045 Serine acetyltransferase; InterPro IPR018357:IPR001451:IPR005881:IPR011004; KEGG: mlu:Mlut_09440 serine O-acetyltransferase; SPTR: D0WRD0 Serine O-acetyltransferase; TIGRFAM: serine O-acetyltransferase; PFAM: Serine acetyltransferase, N-terminal; TIGRFAM: serine O-acetyltransferase.
     
 0.912
Arch_0352
COGs: COG0083 Homoserine kinase; InterPro IPR014721:IPR020568; KEGG: cai:Caci_1201 homoserine kinase; SPTR: D0WRS3 Homoserine kinase.
  
 
 0.841
purU
Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).
  
  
 0.616
thrS
COGs: COG0441 Threonyl-tRNA synthetase; InterProIPR018158:IPR018163:IPR004154:IPR006195:IPR 002320:IPR012947:IPR002314; KEGG: bfa:Bfae_13900 threonyl-tRNA synthetase/Ser-tRNA(Thr) hydrolase; PFAM: tRNA synthetase class II (G H P and S); Threonyl/alanyl tRNA synthetase SAD; Anticodon-binding domain protein; SPTR: D0YSQ6 Threonyl-tRNA synthetase; TIGRFAM: threonyl-tRNA synthetase; PFAM: Anticodon binding domain; Threonyl and Alanyl tRNA synthetase second additional domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: threonyl-tRNA synthetase; Belongs to the class-II [...]
       0.557
Arch_0815
COGs: COG1560 Lauroyl/myristoyl acyltransferase; InterPro IPR004960; KEGG: xce:Xcel_1659 lipid A biosynthesis acyltransferase; PFAM: lipid A biosynthesis acyltransferase; SPTR: D0WQG3 Lipid A biosynthesis lauroyl acyltransferase; PFAM: Bacterial lipid A biosynthesis acyltransferase.
       0.535
Arch_0814
CDP-alcohol phosphatidyltransferase; COGs: COG0558 Phosphatidylglycerophosphate synthase; InterPro IPR017871:IPR000462; KEGG: xce:Xcel_1658 CDP-alcohol phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; SPTR: D0WQG4 Putative CDP-alcohol phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
       0.526
Arch_0819
NUDIX hydrolase; InterPro IPR020476:IPR015797:IPR020084:IPR000086; KEGG: bcv:Bcav_1987 NUDIX hydrolase; PFAM: NUDIX hydrolase; SPTR: D0WQF9 MutT/NUDIX family protein; PFAM: NUDIX domain; Belongs to the Nudix hydrolase family.
       0.526
Arch_0816
COGs: COG0438 Glycosyltransferase; InterPro IPR001296; KEGG: xce:Xcel_1660 glycosyl transferase group 1; PFAM: glycosyl transferase group 1; SPTR: D0WQG2 Phosphatidylinositol alpha-mannosyltransferase; PFAM: Glycosyl transferases group 1.
       0.520
Arch_0817
KEGG: xce:Xcel_1661 hypothetical protein; SPTR: D0WQG1 Putative uncharacterized protein.
       0.520
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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