STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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[Homology]
Score
Arch_0820Protein of unknown function DUF28; COGs: COG0217 conserved hypothetical protein; InterPro IPR002876:IPR017856; KEGG: ami:Amir_2110 protein of unknown function DUF28; PFAM: protein of unknown function DUF28; SPTR: D0WQF1 Protein YebC; PFAM: Domain of unknown function DUF28; TIGRFAM: conserved hypothetical protein TIGR01033. (254 aa)    
Predicted Functional Partners:
ruvC
Crossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.
 
  
 0.891
ruvB
Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
 
   
 0.789
rplS
Ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
  
   0.768
ruvA
Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
     
 0.768
rplQ
COGs: COG0203 Ribosomal protein L17; InterPro IPR000456; KEGG: xce:Xcel_0655 ribosomal protein L17; PFAM: ribosomal protein L17; SPTR: D0WP86 Ribosomal protein L17; TIGRFAM: ribosomal protein L17; PFAM: Ribosomal protein L17; TIGRFAM: ribosomal protein L17.
 
   0.753
thrS
COGs: COG0441 Threonyl-tRNA synthetase; InterProIPR018158:IPR018163:IPR004154:IPR006195:IPR 002320:IPR012947:IPR002314; KEGG: bfa:Bfae_13900 threonyl-tRNA synthetase/Ser-tRNA(Thr) hydrolase; PFAM: tRNA synthetase class II (G H P and S); Threonyl/alanyl tRNA synthetase SAD; Anticodon-binding domain protein; SPTR: D0YSQ6 Threonyl-tRNA synthetase; TIGRFAM: threonyl-tRNA synthetase; PFAM: Anticodon binding domain; Threonyl and Alanyl tRNA synthetase second additional domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: threonyl-tRNA synthetase; Belongs to the class-II [...]
  
  
 0.715
Arch_0819
NUDIX hydrolase; InterPro IPR020476:IPR015797:IPR020084:IPR000086; KEGG: bcv:Bcav_1987 NUDIX hydrolase; PFAM: NUDIX hydrolase; SPTR: D0WQF9 MutT/NUDIX family protein; PFAM: NUDIX domain; Belongs to the Nudix hydrolase family.
       0.688
Arch_0814
CDP-alcohol phosphatidyltransferase; COGs: COG0558 Phosphatidylglycerophosphate synthase; InterPro IPR017871:IPR000462; KEGG: xce:Xcel_1658 CDP-alcohol phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; SPTR: D0WQG4 Putative CDP-alcohol phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
       0.683
Arch_0815
COGs: COG1560 Lauroyl/myristoyl acyltransferase; InterPro IPR004960; KEGG: xce:Xcel_1659 lipid A biosynthesis acyltransferase; PFAM: lipid A biosynthesis acyltransferase; SPTR: D0WQG3 Lipid A biosynthesis lauroyl acyltransferase; PFAM: Bacterial lipid A biosynthesis acyltransferase.
       0.683
rpsP
COGs: COG0228 Ribosomal protein S16; InterPro IPR000307:IPR020592; KEGG: bad:BAD_0209 30S ribosomal protein S16; PFAM: ribosomal protein S16; SPTR: A0ZZV7 30S ribosomal protein S16; TIGRFAM: ribosomal protein S16; PFAM: Ribosomal protein S16; TIGRFAM: ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family.
 
   0.676
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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