STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
Arch_0855Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (433 aa)    
Predicted Functional Partners:
coaD
Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.
 
  
 0.976
coaA
COGs: COG1072 Panthothenate kinase; InterPro IPR004566; KEGG: xce:Xcel_0666 pantothenate kinase; SPTR: A7B9K0 Putative uncharacterized protein; TIGRFAM: pantothenate kinase; PFAM: Phosphoribulokinase / Uridine kinase family; TIGRFAM: pantothenate kinase, bacterial type.
   
 
 0.944
panC
Pantoate/beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
 
 
 0.892
rpoZ
DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
  
    0.877
Arch_1404
Aminotransferase class I and II; COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterProIPR004839:IPR015421:IPR015424:IPR001176:IPR 004838; KEGG: bcv:Bcav_3164 aminotransferase class I and II; PFAM: aminotransferase class I and II; SPTR: D0WPG0 Aspartate transaminase; PFAM: Aminotransferase class I and II.
  
  0.859
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
 
 
 0.850
Arch_0857
Primosome assembly protein PriA; COGs: COG1198 Primosomal protein N' (replication factor Y) - superfamily II helicase; KEGG: tfu:Tfu_1073 primosome assembly protein PriA; SPTR: D0WMZ0 Primosomal protein; TIGRFAM: primosomal protein N'; glutamate--cysteine ligase/gamma-glutamylcysteine synthetase, Streptococcus agalactiae type.
  
    0.842
Arch_0477
COGs: COG0031 Cysteine synthase; InterPro IPR001216:IPR001926:IPR005856:IPR005859; KEGG: xce:Xcel_1111 cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: D0WRC9 Cysteine synthase A; TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; Belongs to the cysteine synthase/cystathionine beta- synthase family.
    
  0.823
Arch_0859
Fmu (Sun) domain protein; COGs: COG0144 tRNA and rRNA cytosine-C5-methylase; InterPro IPR006027:IPR001678; KEGG: jde:Jden_1312 Fmu (Sun) domain protein; PFAM: Fmu (Sun) domain protein; NusB/RsmB/TIM44; SPTR: D0WMY6 Ribosomal RNA small subunit methyltransferase B; PFAM: NOL1/NOP2/sun family; NusB family; TIGRFAM: ribosomal RNA small subunit methyltransferase RsmB; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
 
    0.821
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
 
  
 0.801
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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