STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Arch_1010Sodium/proline symporter; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (524 aa)    
Predicted Functional Partners:
apt
Phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
   
  
 0.720
Arch_0049
COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590:IPR016162:IPR010061:IPR016161; KEGG: pac:PPA0461 methylmalonic acid semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: C0W6L2 Methylmalonate-semialdehyde dehydrogenase (Acylating); TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde dehydrogenase family; TIGRFAM: methylmalonic acid semialdehyde dehydrogenase.
  
  
 0.714
whiB-4
Transcription factor WhiB; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.
   
  
 0.711
Arch_0486
COGs: COG1966 Carbon starvation protein predicted membrane protein; InterPro IPR003706; KEGG: krh:KRH_18870 carbon starvation protein; PFAM: carbon starvation protein CstA; SPTR: D0WP83 Carbon starvation protein A; PFAM: Carbon starvation protein CstA.
  
    0.693
lexA
Transcriptional repressor, LexA family; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
  
  
 0.620
Arch_1485
Sodium:neurotransmitter symporter; COGs: COG0733 Na+-dependent transporter of the SNF family; InterPro IPR000175; KEGG: ckp:ckrop_0020 putative transporter of the neurotransmitter:sodium syporter family; PFAM: sodium:neurotransmitter symporter; SPTR: C4LGC4 Transporter; PFAM: Sodium:neurotransmitter symporter family; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
 
  
 0.576
Arch_1425
KEGG: xce:Xcel_2550 hypothetical protein; SPTR: D1BWZ7 Putative uncharacterized protein; TIGRFAM: conserved hypothetical protein TIGR03089.
  
  
 0.562
Arch_1009
Hypothetical protein.
       0.548
Arch_0028
COGs: COG1292 Choline-glycine betaine transporter; InterPro IPR000060:IPR018093; KEGG: cgt:cgR_1005 hypothetical protein; PFAM: BCCT transporter; SPTR: C8NW06 BCCT family osmoprotectant transporter; TIGRFAM: choline/carnitine/betaine transporter; PFAM: BCCT family transporter; TIGRFAM: choline/carnitine/betaine transport; Belongs to the BCCT transporter (TC 2.A.15) family.
 
  
 0.510
Arch_0426
Protein of unknown function DUF1212; COGs: COG2966 conserved hypothetical protein; InterPro IPR010619; KEGG: rmu:RMDY18_06380 hypothetical protein; PFAM: protein of unknown function DUF1212; SPTR: C0W2A9 Putative uncharacterized protein; PFAM: Protein of unknown function (DUF1212).
       0.493
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.