STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Arch_1053N-6 DNA methylase; COGs: COG0286 Type I restriction-modification system methyltransferase subunit; InterPro IPR002052:IPR003356:IPR002296; KEGG: apa:APP7_1530 type I restriction-modification system, M subunit; PFAM: N-6 DNA methylase; SPTR: B3H2F7 Type I restriction-modification system, M subunit; PFAM: N-6 DNA Methylase; HsdM N-terminal domain. (490 aa)    
Predicted Functional Partners:
Arch_1052
Restriction modification system DNA specificity domain protein; COGs: COG0732 Restriction endonuclease S subunits; InterPro IPR000055; KEGG: vei:Veis_1015 restriction modification system DNA specificity subunit; PFAM: restriction modification system DNA specificity domain; SPTR: B2N0G8 Putative type I restriction-modification system, S subunit; PFAM: Type I restriction modification DNA specificity domain.
 
 
 0.995
Arch_1051
Restriction modification system DNA specificity domain protein; COGs: COG0732 Restriction endonuclease S subunits; InterPro IPR000055; KEGG: bpt:Bpet3989 type I restriction-modification system, S subunit; PFAM: restriction modification system DNA specificity domain; SPTR: A9I6S0 Type I restriction-modification system, S subunit; manually curated; PFAM: Type I restriction modification DNA specificity domain.
 
 
 0.991
Arch_1054
COGs: COG4096 Type I site-specific restriction-modification system R (restriction) subunit and related helicase; InterProIPR014021:IPR001650:IPR014001:IPR007409:IPR 006935:IPR013670; KEGG: pnu:Pnuc_1134 EcoEI R domain-containing protein; PFAM: EcoEI R domain protein; type III restriction protein res subunit; protein of unknown function DUF450; helicase domain protein; PRIAM: Type I site-specific deoxyribonuclease; SMART: DEAD-like helicase; SPTR: A4SXY6 EcoEI R, C-terminal domain protein; PFAM: Type I restriction enzyme R protein N terminus (HSDR_N); EcoEI R protein C-terminal; Type II [...]
 
 
 0.980
Arch_1055
Hypothetical protein; KEGG: ACAS2; acetyl-coenzyme a synthetase; SPTR: B8C359 Acetyl-coenzyme a synthetase (Fragment).
       0.752
Arch_1050
Hypothetical protein; KEGG: rsq:Rsph17025_1504 RND family efflux transporter MFP subunit; SPTR: D0YUX9 Putative uncharacterized protein.
       0.625
uvrB
Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
    
 
 0.414
Arch_1057
Domain of unknown function DUF1814; InterPro IPR014942; KEGG: ere:EUBREC_3503 hypothetical protein; PFAM: Domain of unknown function DUF1814; SPTR: A8RVS1 Putative uncharacterized protein; PFAM: Domain of unknown function (DUF1814).
     
 0.409
Arch_0519
DNA methylase N-4/N-6 domain protein; COGs: COG0863 DNA modification methylase; InterProIPR002052:IPR002295:IPR003115:IPR002941:IPR 015840; KEGG: pac:PPA1586 ParB family DNA methylase; PFAM: DNA methylase N-4/N-6 domain protein; ParB domain protein nuclease; SMART: ParB domain protein nuclease; SPTR: C2KNX9 ParB family DNA methylase; manually curated; PFAM: ParB-like nuclease domain; DNA methylase.
  
  
 0.405
Your Current Organism:
Arcanobacterium haemolyticum
NCBI taxonomy Id: 644284
Other names: A. haemolyticum DSM 20595, Arcanobacterium haemolyticum ATCC 9345, Arcanobacterium haemolyticum CIP 103370, Arcanobacterium haemolyticum DSM 20595, Arcanobacterium haemolyticum str. DSM 20595, Arcanobacterium haemolyticum strain DSM 20595
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.